Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells

Stephen B. Baylin, Susan H. Hsu, Donald S. Gann, Robert C. Smallridge, Samuel A. Wells

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.

Original languageEnglish (US)
Pages (from-to)429-431
Number of pages3
JournalScience
Volume199
Issue number4327
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells'. Together they form a unique fingerprint.

  • Cite this

    Baylin, S. B., Hsu, S. H., Gann, D. S., Smallridge, R. C., & Wells, S. A. (1978). Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells. Science, 199(4327), 429-431. https://doi.org/10.1126/science.619463