Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells

Stephen B. Baylin, Susan H. Hsu, Donald S. Gann, Robert C. Smallridge, Samuel A. Wells

Research output: Contribution to journalArticle

53 Scopus citations


Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.

Original languageEnglish (US)
Pages (from-to)429-431
Number of pages3
Issue number4327
StatePublished - Jan 1 1978


ASJC Scopus subject areas

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