Inherited genetic variation and overall survival following follicular lymphoma

Todd M. Gibson, Sophia S. Wang, James R Cerhan, Matthew J. Maurer, Patricia Hartge, Thomas Matthew Habermann, Scott Davis, Wendy Cozen, Charles F. Lynch, Richard K. Severson, Nathaniel Rothman, Stephen J. Chanock, Lindsay M. Morton

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Abstract

Follicular lymphoma (FL) has variable progression and survival, and improved identification of patients at high risk for progression would aid in identifying patients most likely to benefit from alternative therapy. In a sample of 244 FL cases identified during a population-based case-control study of non-Hodgkin lymphoma (NHL), we examined 6,679 tag SNPs in 488 gene regions for associations with overall FL survival. Over a median follow-up of 89 months with 65 deaths in this preliminary study, we identified 5 gene regions (BMP7, GALNT12, DUSP2, GADD45B, and ADAM17) that were associated with overall survival from FL. Results did not meet the criteria for statistical significance after adjustment for multiple hypothesis testing. These results, which support a role for host factors in determining the variable progression of FL, serve as an initial examination that can inform future studies of genetic variation and FL survival. However, they require replication in independent populations, as well as assessment in rituximab-treated patients.

Original languageEnglish (US)
Pages (from-to)724-726
Number of pages3
JournalAmerican Journal of Hematology
Volume87
Issue number7
DOIs
StatePublished - Jul 2012

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ASJC Scopus subject areas

  • Hematology

Cite this

Gibson, T. M., Wang, S. S., Cerhan, J. R., Maurer, M. J., Hartge, P., Habermann, T. M., Davis, S., Cozen, W., Lynch, C. F., Severson, R. K., Rothman, N., Chanock, S. J., & Morton, L. M. (2012). Inherited genetic variation and overall survival following follicular lymphoma. American Journal of Hematology, 87(7), 724-726. https://doi.org/10.1002/ajh.23184