TY - JOUR
T1 - Inherited genetic variation and overall survival following follicular lymphoma
AU - Gibson, Todd M.
AU - Wang, Sophia S.
AU - Cerhan, James R.
AU - Maurer, Matthew J.
AU - Hartge, Patricia
AU - Habermann, Thomas M.
AU - Davis, Scott
AU - Cozen, Wendy
AU - Lynch, Charles F.
AU - Severson, Richard K.
AU - Rothman, Nathaniel
AU - Chanock, Stephen J.
AU - Morton, Lindsay M.
PY - 2012/7
Y1 - 2012/7
N2 - Follicular lymphoma (FL) has variable progression and survival, and improved identification of patients at high risk for progression would aid in identifying patients most likely to benefit from alternative therapy. In a sample of 244 FL cases identified during a population-based case-control study of non-Hodgkin lymphoma (NHL), we examined 6,679 tag SNPs in 488 gene regions for associations with overall FL survival. Over a median follow-up of 89 months with 65 deaths in this preliminary study, we identified 5 gene regions (BMP7, GALNT12, DUSP2, GADD45B, and ADAM17) that were associated with overall survival from FL. Results did not meet the criteria for statistical significance after adjustment for multiple hypothesis testing. These results, which support a role for host factors in determining the variable progression of FL, serve as an initial examination that can inform future studies of genetic variation and FL survival. However, they require replication in independent populations, as well as assessment in rituximab-treated patients.
AB - Follicular lymphoma (FL) has variable progression and survival, and improved identification of patients at high risk for progression would aid in identifying patients most likely to benefit from alternative therapy. In a sample of 244 FL cases identified during a population-based case-control study of non-Hodgkin lymphoma (NHL), we examined 6,679 tag SNPs in 488 gene regions for associations with overall FL survival. Over a median follow-up of 89 months with 65 deaths in this preliminary study, we identified 5 gene regions (BMP7, GALNT12, DUSP2, GADD45B, and ADAM17) that were associated with overall survival from FL. Results did not meet the criteria for statistical significance after adjustment for multiple hypothesis testing. These results, which support a role for host factors in determining the variable progression of FL, serve as an initial examination that can inform future studies of genetic variation and FL survival. However, they require replication in independent populations, as well as assessment in rituximab-treated patients.
UR - http://www.scopus.com/inward/record.url?scp=84862550386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862550386&partnerID=8YFLogxK
U2 - 10.1002/ajh.23184
DO - 10.1002/ajh.23184
M3 - Letter
C2 - 22473939
AN - SCOPUS:84862550386
SN - 0361-8609
VL - 87
SP - 724
EP - 726
JO - American journal of hematology
JF - American journal of hematology
IS - 7
ER -