Inheritance of low serum immunoglobulin D

S. L. Dunnette, G. J. Gleich, Richard M Weinshilboum

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Previous studies have shown that low IgD levels in normal individuals are distributed in a nonunimodal manner. Therefore, in this study we tested whether inheritance might play a role in determination of IgD levels. IgD levels were measured in serum or plasma from 301 randomly selected children aged 6-18 yr, 245 consecutive adult blood donors, and 134 first-degree relatives of subjects with low IgD levels. Comparison of serum and plasma from five individuals revealed no difference, so the two were used interchangeably. The distributions of log IgD levels in randomly selected populations of both adults and children were nonunimodal with nadirs at 2.15 IU/ml. In both of these randomly selected populations, 13-14% of the subjects had low IgD values (<2.15 IU/ml). In addition, there was a significant sibling-sibling correlation of log IgD values (r=0.56, n=72, P<0.01). Because of the nonunimodality of the frequency distribution histogram for IgD values and because of the familial aggregation of these values, the study was extended to include first-degree relatives of subjects with low plasma IgD. Blood samples from 92% of living first-degree relatives, 134 individuals, were analyzed for their level of IgD, and the results of segregation and pedigree analyses of these data were compatible with autosomal recessive inheritance of an allele for low plasma IgD levels. IgD values in plasma from siblings of probands for low IgD were also non-unimodal in distribution with a nadir at ≃2.15 IU/ml. The results suggest that there is autosomal recessive inheritance of an allele for low plasma IgD.

Original languageEnglish (US)
Pages (from-to)248-255
Number of pages8
JournalJournal of Clinical Investigation
Volume62
Issue number2
StatePublished - 1978

Fingerprint

Immunoglobulin D
Serum
Siblings
Alleles
Pedigree
Blood Donors
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Inheritance of low serum immunoglobulin D. / Dunnette, S. L.; Gleich, G. J.; Weinshilboum, Richard M.

In: Journal of Clinical Investigation, Vol. 62, No. 2, 1978, p. 248-255.

Research output: Contribution to journalArticle

Dunnette, SL, Gleich, GJ & Weinshilboum, RM 1978, 'Inheritance of low serum immunoglobulin D', Journal of Clinical Investigation, vol. 62, no. 2, pp. 248-255.
Dunnette, S. L. ; Gleich, G. J. ; Weinshilboum, Richard M. / Inheritance of low serum immunoglobulin D. In: Journal of Clinical Investigation. 1978 ; Vol. 62, No. 2. pp. 248-255.
@article{e026fc952353424291edfa30907ff02e,
title = "Inheritance of low serum immunoglobulin D",
abstract = "Previous studies have shown that low IgD levels in normal individuals are distributed in a nonunimodal manner. Therefore, in this study we tested whether inheritance might play a role in determination of IgD levels. IgD levels were measured in serum or plasma from 301 randomly selected children aged 6-18 yr, 245 consecutive adult blood donors, and 134 first-degree relatives of subjects with low IgD levels. Comparison of serum and plasma from five individuals revealed no difference, so the two were used interchangeably. The distributions of log IgD levels in randomly selected populations of both adults and children were nonunimodal with nadirs at 2.15 IU/ml. In both of these randomly selected populations, 13-14{\%} of the subjects had low IgD values (<2.15 IU/ml). In addition, there was a significant sibling-sibling correlation of log IgD values (r=0.56, n=72, P<0.01). Because of the nonunimodality of the frequency distribution histogram for IgD values and because of the familial aggregation of these values, the study was extended to include first-degree relatives of subjects with low plasma IgD. Blood samples from 92{\%} of living first-degree relatives, 134 individuals, were analyzed for their level of IgD, and the results of segregation and pedigree analyses of these data were compatible with autosomal recessive inheritance of an allele for low plasma IgD levels. IgD values in plasma from siblings of probands for low IgD were also non-unimodal in distribution with a nadir at ≃2.15 IU/ml. The results suggest that there is autosomal recessive inheritance of an allele for low plasma IgD.",
author = "Dunnette, {S. L.} and Gleich, {G. J.} and Weinshilboum, {Richard M}",
year = "1978",
language = "English (US)",
volume = "62",
pages = "248--255",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "2",

}

TY - JOUR

T1 - Inheritance of low serum immunoglobulin D

AU - Dunnette, S. L.

AU - Gleich, G. J.

AU - Weinshilboum, Richard M

PY - 1978

Y1 - 1978

N2 - Previous studies have shown that low IgD levels in normal individuals are distributed in a nonunimodal manner. Therefore, in this study we tested whether inheritance might play a role in determination of IgD levels. IgD levels were measured in serum or plasma from 301 randomly selected children aged 6-18 yr, 245 consecutive adult blood donors, and 134 first-degree relatives of subjects with low IgD levels. Comparison of serum and plasma from five individuals revealed no difference, so the two were used interchangeably. The distributions of log IgD levels in randomly selected populations of both adults and children were nonunimodal with nadirs at 2.15 IU/ml. In both of these randomly selected populations, 13-14% of the subjects had low IgD values (<2.15 IU/ml). In addition, there was a significant sibling-sibling correlation of log IgD values (r=0.56, n=72, P<0.01). Because of the nonunimodality of the frequency distribution histogram for IgD values and because of the familial aggregation of these values, the study was extended to include first-degree relatives of subjects with low plasma IgD. Blood samples from 92% of living first-degree relatives, 134 individuals, were analyzed for their level of IgD, and the results of segregation and pedigree analyses of these data were compatible with autosomal recessive inheritance of an allele for low plasma IgD levels. IgD values in plasma from siblings of probands for low IgD were also non-unimodal in distribution with a nadir at ≃2.15 IU/ml. The results suggest that there is autosomal recessive inheritance of an allele for low plasma IgD.

AB - Previous studies have shown that low IgD levels in normal individuals are distributed in a nonunimodal manner. Therefore, in this study we tested whether inheritance might play a role in determination of IgD levels. IgD levels were measured in serum or plasma from 301 randomly selected children aged 6-18 yr, 245 consecutive adult blood donors, and 134 first-degree relatives of subjects with low IgD levels. Comparison of serum and plasma from five individuals revealed no difference, so the two were used interchangeably. The distributions of log IgD levels in randomly selected populations of both adults and children were nonunimodal with nadirs at 2.15 IU/ml. In both of these randomly selected populations, 13-14% of the subjects had low IgD values (<2.15 IU/ml). In addition, there was a significant sibling-sibling correlation of log IgD values (r=0.56, n=72, P<0.01). Because of the nonunimodality of the frequency distribution histogram for IgD values and because of the familial aggregation of these values, the study was extended to include first-degree relatives of subjects with low plasma IgD. Blood samples from 92% of living first-degree relatives, 134 individuals, were analyzed for their level of IgD, and the results of segregation and pedigree analyses of these data were compatible with autosomal recessive inheritance of an allele for low plasma IgD levels. IgD values in plasma from siblings of probands for low IgD were also non-unimodal in distribution with a nadir at ≃2.15 IU/ml. The results suggest that there is autosomal recessive inheritance of an allele for low plasma IgD.

UR - http://www.scopus.com/inward/record.url?scp=0018152121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018152121&partnerID=8YFLogxK

M3 - Article

VL - 62

SP - 248

EP - 255

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 2

ER -