Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity

R. Arlen Price, N. J. Cox, R. S. Spielman, J. A. Van Loon, B. L. Maidak, Richard M Weinshilboum

Research output: Contribution to journalArticle

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Abstract

Sulfate conjugation is an important pathway in the biotransformation of drugs and neurotransmitters. The thermolabile (TL) form of the enzyme phenol sulfotransferase (PST) catalyzes the sulfation of cathecholamine neurotransmitters and drugs such as methyldopa and acetaminophen. Platelet TL PST activity was measured in blood samples from 232 individuals in 49 nuclear families. Correlations ranged from 0.43 to 0.45 for parent-offspring pairs and from 0.44 to 0.47 for siblings. Mother-father correlations were not significantly different from zero. Although evidence was not unequivocal, both segregation and commingling analyses provided some support for a major gene influence on TL PST activity, with other variation due to polygenic background. In both sets of analyses, however, support for a major gene hypothesis depended upon skewness in the TL PST activity distribution. A polygenic model with high heritability (0.77) was most strongly supported with the log transformed data. These results confirm and extend a previous report of high heritability of TL PST based on a study of twins. In addition, our results raise the possibility of a major gene effect on this important catecholamine- and drug-metabolizing enzyme - a possibility that can now be evaluated using biochemical techniques.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalGenetic Epidemiology
Volume5
Issue number1
StatePublished - 1988

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Arylsulfotransferase
Blood Platelets
Neurotransmitter Agents
Pharmaceutical Preparations
Genes
Methyldopa
Twin Studies
Enzymes
Acetaminophen
Biotransformation
Nuclear Family
Fathers
Sulfates
Catecholamines
Siblings
Mothers

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Cite this

Arlen Price, R., Cox, N. J., Spielman, R. S., Van Loon, J. A., Maidak, B. L., & Weinshilboum, R. M. (1988). Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity. Genetic Epidemiology, 5(1), 1-15.

Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity. / Arlen Price, R.; Cox, N. J.; Spielman, R. S.; Van Loon, J. A.; Maidak, B. L.; Weinshilboum, Richard M.

In: Genetic Epidemiology, Vol. 5, No. 1, 1988, p. 1-15.

Research output: Contribution to journalArticle

Arlen Price, R, Cox, NJ, Spielman, RS, Van Loon, JA, Maidak, BL & Weinshilboum, RM 1988, 'Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity', Genetic Epidemiology, vol. 5, no. 1, pp. 1-15.
Arlen Price, R. ; Cox, N. J. ; Spielman, R. S. ; Van Loon, J. A. ; Maidak, B. L. ; Weinshilboum, Richard M. / Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity. In: Genetic Epidemiology. 1988 ; Vol. 5, No. 1. pp. 1-15.
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