Infused peripheral blood autograft absolute lymphocyte count correlates with day 15 absolute lymphocyte count and clinical outcome after autologous peripheral hematopoietic stem cell transplantation in non-Hodgkin's lymphoma

L. F. Porrata, M. R. Lotzow, D. J. Inwards, D. A. Gastineau, S. B. Moore, A. A. Pineda, K. L. Bundy, D. J. Padley, D. Persky, S. M. Ansell, I. N.M. Micaleef, Svetomir N. Markovic

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Absolute lymphocyte count at day 15 (ALC-15) after autologous peripheral blood hematopoietic stem cell transplantation (APHSCT) is an independent prognostic factor for survival in non-Hodgkin's lymphoma (NHL). Factors affecting ALC-15 remain unknown. We hypothesized that dose of infused autograft lymphocytes (A-ALC) directly impacts upon ALC-15. A total of 190 consecutive NHL patients received A-ALC between 1993 and 2001. The primary end point was correlation between A-ALC and ALC-15. A strong correlation was identified (r = 0.71). A higher A-ALC was infused into patients achieving an ALC-15 ≥500/μl vs ALC-15 <500/μl (median of 0.68 × 109/kg (0.04-2.21 × 109/kg), vs 0.34 × 109/kg (0.04-1.42 × 109/kg), P < 0.0001). The median follow-up for all patients was 36 months (maximum of 109 months). The A-ALC threshold was determined at 0.5 × 109/kg. The median overall survival (OS) and progression-free survival (PFS) times were longer in patients who received an A-ALC ≥ 0.5 × 109/kg vs A-ALC <0.5 × 109/kg (76 vs 17 months, P < 0.0001; 49 vs 10 months, P<0.0001, respectively). Multivariate analysis demonstrated A-ALC to be an independent prognostic indicator for OS and PFS. These data support our hypothesis that ALC-15 and survival are dependent upon the dose of infused A-ALC in NHL.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalBone Marrow Transplantation
Volume33
Issue number3
DOIs
StatePublished - Feb 2004

Keywords

  • Absolute lymphocyte recovery
  • Autologous peripheral blood hematopoietic stem cell transplantation
  • Infused peripheral blood autograft absolute lymphocyte count

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Infused peripheral blood autograft absolute lymphocyte count correlates with day 15 absolute lymphocyte count and clinical outcome after autologous peripheral hematopoietic stem cell transplantation in non-Hodgkin's lymphoma'. Together they form a unique fingerprint.

Cite this