Informing therapeutic lymphadenectomy: Location of regional metastatic lymph nodes in adrenocortical carcinoma

Alaa Sada, Amy E. Glasgow, Melanie L. Lyden, Benzon M. Dy, Trenton R. Foster, Elizabeth B. Habermann, Irina Bancos, Travis J. McKenzie

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The anatomic boundaries of lymphadenectomy for adrenocortical carcinoma (ACC) are not defined. Methods: Adults undergoing resection of ACC were included. Locations were categorized based on positive LN locations on final pathology. Results: Of 231 resected ACC, 6% had positive LN during initial resection. Positive LN in left ACC (n = 7) were: 2 para-aortic, 2 left renal-hilar, 1 para-aortic and left renal-hilar and 1 unknown, while for right ACC (n = 7): 2 para-caval, 1 para-caval and right renal-hilar, 1 inter-aortocaval, 1 celiac, 1 para-aortic, and 1 unknown. Of 55 resections for recurrent ACC, positive LN in left ACC (n = 2) were: 1 para-aortic, and 1 para-aortic with left renal-hilar, while LN for right ACC (n = 7): 2 inter-aortocaval, 2 right renal-hilar, 2 para-caval and one retrocrural. Conclusion: The most common LN metastases are para-caval for right, and para-aortic and left renal-hilar for left ACC. Further studies are necessary to determine the boundaries of lymphadenectomy in ACC resection.

Original languageEnglish (US)
JournalAmerican journal of surgery
DOIs
StateAccepted/In press - 2021

Keywords

  • Adrenocortical carcinoma
  • Lymph nodes
  • Lymphadenectomy

ASJC Scopus subject areas

  • Surgery

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