Informed development of drugs acting at Family B G protein-coupled receptors

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Rational refinement and development of receptor-active ligands can come from high-resolution insights into the structures of these potential drug targets. Structural insights for Family A G protein-coupled receptors (GPCRs) have been advanced substantially with the recently reported crystal structure of the intact β2-adrenergic receptor. While high-resolution structural insights for Family B GPCRs are also advancing, this is currently limited to the functionally important extracellular amino-terminal tail domain of those receptors. The current report describes how these structures can provide leads for the development of small-molecule agonist drugs acting at Family B GPCRs. Endogenous agonist activity within the amino terminus of these receptors could be key for the development of such drugs.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages203-209
Number of pages7
Volume1144
DOIs
StatePublished - Nov 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1144
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

G-Protein-Coupled Receptors
Pharmaceutical Preparations
Adrenergic Receptors
Crystal structure
Ligands
Molecules

Keywords

  • Activation mechanisms
  • G protein-coupled receptors
  • Ligand binding
  • Receptor structure
  • Secretin receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Miller, L. J. (2008). Informed development of drugs acting at Family B G protein-coupled receptors. In Annals of the New York Academy of Sciences (Vol. 1144, pp. 203-209). (Annals of the New York Academy of Sciences; Vol. 1144). https://doi.org/10.1196/annals.1418.001

Informed development of drugs acting at Family B G protein-coupled receptors. / Miller, Laurence J.

Annals of the New York Academy of Sciences. Vol. 1144 2008. p. 203-209 (Annals of the New York Academy of Sciences; Vol. 1144).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Miller, LJ 2008, Informed development of drugs acting at Family B G protein-coupled receptors. in Annals of the New York Academy of Sciences. vol. 1144, Annals of the New York Academy of Sciences, vol. 1144, pp. 203-209. https://doi.org/10.1196/annals.1418.001
Miller LJ. Informed development of drugs acting at Family B G protein-coupled receptors. In Annals of the New York Academy of Sciences. Vol. 1144. 2008. p. 203-209. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1418.001
Miller, Laurence J. / Informed development of drugs acting at Family B G protein-coupled receptors. Annals of the New York Academy of Sciences. Vol. 1144 2008. pp. 203-209 (Annals of the New York Academy of Sciences).
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