Information of ADME-associated proteins and potential application for pharmacogenetic prediction of drug responses

C. J. Zheng; L. Y. Han; X. Chen; Z. W. Cao; J. Cui; H. H. Lin; H. L. Zhang; H. Li; Y. Z. Chen

doi:10.2174/157016006776286819

Information of ADME-associated proteins and potential application for pharmacogenetic prediction of drug responses

C. J. Zheng, L. Y. Han, X. Chen, Z. W. Cao, J. Cui, H. H. Lin, H. L. Zhang, H. Li, Y. Z. Chen

Pharmacology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Pharmacogenetic prediction and mechanistic elucidation of individual variations of drug response is important for facilitating the development of personalized medicines and optimum therapeutic dosages. One of the keys to pharmacogenetic studies is the knowledge about proteins responsible for the absorption, distribution, metabolism and excretion (ADME) of drugs. This article describes the web-resources of ADME-associated proteins, assesses the usefulness of the relevant information for facilitating pharmacogenetic prediction of drug responses, and discusses computational methods that explore the relevant information for predicting individual variations of drug response from the polymorphisms of ADME-associated proteins.

Original language	English (US)
Pages (from-to)	87-103
Number of pages	17
Journal	Current Pharmacogenomics
Volume	4
Issue number	2
DOIs	https://doi.org/10.2174/157016006776286819
State	Published - Jun 2006

Keywords

Carrier
Drug design
Drug development
Drug discovery
Drug metabolizing enzyme
Drug target
Ligand-binding protein
Pharmacogenetics
Pharmacogenomics
Pharmacokinetics
Transporter

ASJC Scopus subject areas

Genetics
Pharmacology

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10.2174/157016006776286819

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abstract = "Pharmacogenetic prediction and mechanistic elucidation of individual variations of drug response is important for facilitating the development of personalized medicines and optimum therapeutic dosages. One of the keys to pharmacogenetic studies is the knowledge about proteins responsible for the absorption, distribution, metabolism and excretion (ADME) of drugs. This article describes the web-resources of ADME-associated proteins, assesses the usefulness of the relevant information for facilitating pharmacogenetic prediction of drug responses, and discusses computational methods that explore the relevant information for predicting individual variations of drug response from the polymorphisms of ADME-associated proteins.",

keywords = "Carrier, Drug design, Drug development, Drug discovery, Drug metabolizing enzyme, Drug target, Ligand-binding protein, Pharmacogenetics, Pharmacogenomics, Pharmacokinetics, Transporter",

author = "Zheng, {C. J.} and Han, {L. Y.} and X. Chen and Cao, {Z. W.} and J. Cui and Lin, {H. H.} and Zhang, {H. L.} and H. Li and Chen, {Y. Z.}",

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language = "English (US)",

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journal = "Current Pharmacogenomics",

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AU - Zheng, C. J.

AU - Han, L. Y.

AU - Chen, X.

AU - Cao, Z. W.

AU - Cui, J.

AU - Lin, H. H.

AU - Zhang, H. L.

AU - Li, H.

AU - Chen, Y. Z.

PY - 2006/6

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AB - Pharmacogenetic prediction and mechanistic elucidation of individual variations of drug response is important for facilitating the development of personalized medicines and optimum therapeutic dosages. One of the keys to pharmacogenetic studies is the knowledge about proteins responsible for the absorption, distribution, metabolism and excretion (ADME) of drugs. This article describes the web-resources of ADME-associated proteins, assesses the usefulness of the relevant information for facilitating pharmacogenetic prediction of drug responses, and discusses computational methods that explore the relevant information for predicting individual variations of drug response from the polymorphisms of ADME-associated proteins.

KW - Carrier

KW - Drug design

KW - Drug development

KW - Drug discovery

KW - Drug metabolizing enzyme

KW - Drug target

KW - Ligand-binding protein

KW - Pharmacogenetics

KW - Pharmacogenomics

KW - Pharmacokinetics

KW - Transporter

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Information of ADME-associated proteins and potential application for pharmacogenetic prediction of drug responses

Abstract

Keywords

ASJC Scopus subject areas

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