TY - JOUR
T1 - Influenza infection in neutropenic adults
AU - Durani, Urshila
AU - Dioverti Prono, Maria V.
AU - Tosh, Pritish K.
AU - Patnaik, Mrinal M
AU - Barreto, Jason N.
AU - Tande, Aaron J.
PY - 2016/9/14
Y1 - 2016/9/14
N2 - While lymphopenia is a well-defined risk factor for severe influenza, the effect of neutropenia is unknown. This was a retrospective single centre study of adult patients with documented neutropenia and influenza between 2005 and 2013. Forty patients were included with a median follow-up of 2 years (IQR 0.8–4.0). Median ANC at influenza diagnosis was 0.3 × 109/L (IQR 0.1–0.4 × 109/L). Outcomes included hospitalization (N = 28, 70%), pneumonia (N = 9, 23%), ICU admission (N = 9, 23%) and mechanical ventilation (N = 7, 18%). Three deaths (7.5%) were attributed to influenza, all of whom had lower respiratory tract infection (LRTI). Patients with LRTI (N = 18, 45%) also had a higher 30-day mortality (37 versus 0%) and 90-day mortality (42 versus 0%) than those with upper respiratory tract infection. In summary, neutropenic patients have high rates of influenza complications. Our study highlights the need for early diagnosis and aggressive management of influenza in this population.
AB - While lymphopenia is a well-defined risk factor for severe influenza, the effect of neutropenia is unknown. This was a retrospective single centre study of adult patients with documented neutropenia and influenza between 2005 and 2013. Forty patients were included with a median follow-up of 2 years (IQR 0.8–4.0). Median ANC at influenza diagnosis was 0.3 × 109/L (IQR 0.1–0.4 × 109/L). Outcomes included hospitalization (N = 28, 70%), pneumonia (N = 9, 23%), ICU admission (N = 9, 23%) and mechanical ventilation (N = 7, 18%). Three deaths (7.5%) were attributed to influenza, all of whom had lower respiratory tract infection (LRTI). Patients with LRTI (N = 18, 45%) also had a higher 30-day mortality (37 versus 0%) and 90-day mortality (42 versus 0%) than those with upper respiratory tract infection. In summary, neutropenic patients have high rates of influenza complications. Our study highlights the need for early diagnosis and aggressive management of influenza in this population.
KW - immunocompromised host
KW - influenza virus
KW - neutropenia
KW - Respiratory tract infection
UR - http://www.scopus.com/inward/record.url?scp=84987851300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84987851300&partnerID=8YFLogxK
U2 - 10.1080/23744235.2016.1231418
DO - 10.1080/23744235.2016.1231418
M3 - Article
C2 - 27636702
AN - SCOPUS:84987851300
SP - 1
EP - 6
JO - Infectious diseases (London, England)
JF - Infectious diseases (London, England)
SN - 2374-4235
ER -