Influence of the Metaboreflex on Pulmonary Vascular Capacitance in Heart Failure

Erik H. Van Iterson, Eric M. Snyder, Bruce D. Johnson, Thomas P. Olson

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose An impaired metaboreflex is associated with abnormal ventilatory and peripheral vascular function in heart failure (HF), whereas its influence on cardiac function or pulmonary vascular pressure remains unclear. We aimed to assess whether metabolite-sensitive neural feedback (metaboreflex) from locomotor muscles via postexercise regional circulatory occlusion (RCO) attenuates pulmonary vascular capacitance (GXCAP) and/or circulatory power (CircP) in patients with HF. Methods Eleven patients with HF (NYHA class, I/II; ages, 51 ± 15 yr; ejection fraction, 32% ± 9%) and 11 age-and gender-matched controls (ages, 43 ± 9 yr) completed three cycling sessions (4 min, 60% peak oxygen uptake (VO2)). Session 1 was a control trial including normal recovery (NR). Session 2 or 3 included bilateral upper thigh pressure tourniquets inflated suprasystolic at end of exercise (RCO) for 2-min recovery with or without inspired CO2 (RCO + CO2) (randomized). Mean arterial pressure, HR, and VO2 were continuously measured. Estimates of central hemodynamics; CircP = (VO2 × mean arterial pressure)/weight; oxygen pulse index (O2pulseI = (VO2/HR)/body surface area); and GXCAP = O2pulseI × end-tidal partial pressure CO2 were calculated. Results At rest and end of exercise, CircP and GXCAP were lower in HF versus those in controls (P < 0.05), with no differences between transients (P > 0.05). At 2-min recovery, GXCAP was lower during RCO versus that during NR in both groups (72 ± 23 vs 98 ± 20 and 73 ± 34 vs 114 ± 35 mL·beat-1·mm Hg·m-2, respectively; P < 0.05), whereas CircP did not differ between transients (P > 0.05). Differences (% and Δ) between baseline and 2-min recovery among transients suggest that metaboreflex attenuates GXCAP in HF. Differences (% and Δ) between baseline and 2-min recovery among transients suggest that metaboreflex may attenuate CircP in controls. Conclusions The present observations suggest that locomotor muscle metaboreflex activation may influence CircP in controls but not in HF. However, metaboreflex activation may evoke decreases in GXCAP (increased pulmonary vascular pressures) in HF and controls.

Original languageEnglish (US)
Pages (from-to)353-362
Number of pages10
JournalMedicine and science in sports and exercise
Volume48
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • CARDIAC POWER
  • CIRCULATORY POWER
  • ERGORECEPTOR
  • MECHANORECEPTOR
  • METABORECEPTOR

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Fingerprint Dive into the research topics of 'Influence of the Metaboreflex on Pulmonary Vascular Capacitance in Heart Failure'. Together they form a unique fingerprint.

  • Cite this