Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women

Christopher T. Minson, John R. Halliwill, Tamica M. Young, Michael Joseph Joyner

Research output: Contribution to journalArticle

340 Citations (Scopus)

Abstract

Background - Our goal was to test sympathetic and cardiovagal baroreflex sensitivity and the transduction of sympathetic traffic into vascular resistance during the early follicular (EF) and midluteal (ML) phases of the menstrual cycle. Methods and Results - Sympathetic baroreflex sensitivity was assessed by lowering and raising blood pressure with intravenous bolus doses of sodium nitroprusside and phenylephrine. It was defined as the slope relating muscle sympathetic nerve activity (MSNA; determined by microneurography) and diastolic blood pressure. Cardiovagal baroreflex sensitivity was defined as the slope relating R-R interval and systolic blood pressure. Vascular transduction was evaluated during ischemic handgrip exercise and postexercise ischemia, and it was defined as the slope relating MSNA and calf vascular resistance (determined by plethysmography) Resting MSNA (EF, 1170 ± 151 U/min; ML 2252 ± 251 U/min; P < 0.001) and plasma norepinephrine levels (EF, 240 ± 21 pg/mL; ML, 294 ± 25 pg/mL; P=0.025) were significantly higher in the ML than in the EF phase. Furthermore, sympathetic baroreflex sensitivity was greater during the ML than the EF phase in every subject (MSNA/diastolic blood pressure slopes: EF, -4.15; FL, -5.42 P=0.005). No significant differences in cardiovagal baroreflex sensitivity or vascular transduction were observed. Conclusions - The present study suggests that the hormonal fluctuations that occur during the normal menstrual cycle may alter sympathetic outflow but not the transduction of sympathetic activity into vascular resistance.

Original languageEnglish (US)
Pages (from-to)862-868
Number of pages7
JournalCirculation
Volume101
Issue number8
StatePublished - Feb 29 2000

Fingerprint

Baroreflex
Menstrual Cycle
Blood Vessels
Blood Pressure
Follicular Phase
Vascular Resistance
Plethysmography
Nitroprusside
Phenylephrine
Norepinephrine
Ischemia
Exercise
Muscles

Keywords

  • Blood pressure
  • Estrogens
  • Muscles
  • Progesterone
  • Vasculature

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. / Minson, Christopher T.; Halliwill, John R.; Young, Tamica M.; Joyner, Michael Joseph.

In: Circulation, Vol. 101, No. 8, 29.02.2000, p. 862-868.

Research output: Contribution to journalArticle

Minson, Christopher T. ; Halliwill, John R. ; Young, Tamica M. ; Joyner, Michael Joseph. / Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. In: Circulation. 2000 ; Vol. 101, No. 8. pp. 862-868.
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