Influence of sex hormones on the neuromuscular junction

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Motor units in mammalian skeletal muscle are classified based on metabolic and functional properties. The neuromuscular junctions at slow and fast fiber types display remarkable differences in structure and synaptic efficacy. Androgen receptors are present in both motoneurons and muscle fibers, although expression may vary during development. The effects of anabolic-androgenic steroids have been well-characterized in sexually dimorphic muscles. Anabolic-androgenic steroids are clearly necessary for the survival of motoneurons of sexually dimorphic muscles such as the rat bulbocavernosus muscle. Exogenous treatment with anabolic-androgenic steroids can lead to improved synaptic efficacy at neuromuscular junctions by facilitating synaptic vesicle cycling, increasing neurotransmitter synthesis and/or increasing ACh receptor expression. Concurrently, anabolic-androgenic steroids can lead to muscle fiber hypertrophy, which if anything would decrease efficacy of neuromuscular transmission. All of these effects show motor unit type specificity and are enhanced by concomitant resistance training in non-sexually dimorphic muscles.

Original languageEnglish (US)
Title of host publicationAdvances in Molecular and Cell Biology
Pages183-194
Number of pages12
Volume34
DOIs
StatePublished - 2004

Publication series

NameAdvances in Molecular and Cell Biology
Volume34
ISSN (Print)15692558

Fingerprint

Neuromuscular Junction
Gonadal Steroid Hormones
Testosterone Congeners
Muscles
Motor Neurons
Resistance Training
Synaptic Vesicles
Androgen Receptors
Cholinergic Receptors
Hypertrophy
Neurotransmitter Agents
Skeletal Muscle

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Sieck, G. C., & Mantilla, C. B. (2004). Influence of sex hormones on the neuromuscular junction. In Advances in Molecular and Cell Biology (Vol. 34, pp. 183-194). (Advances in Molecular and Cell Biology; Vol. 34). https://doi.org/10.1016/S1569-2558(03)34013-5

Influence of sex hormones on the neuromuscular junction. / Sieck, Gary C; Mantilla, Carlos Bernardo.

Advances in Molecular and Cell Biology. Vol. 34 2004. p. 183-194 (Advances in Molecular and Cell Biology; Vol. 34).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sieck, GC & Mantilla, CB 2004, Influence of sex hormones on the neuromuscular junction. in Advances in Molecular and Cell Biology. vol. 34, Advances in Molecular and Cell Biology, vol. 34, pp. 183-194. https://doi.org/10.1016/S1569-2558(03)34013-5
Sieck GC, Mantilla CB. Influence of sex hormones on the neuromuscular junction. In Advances in Molecular and Cell Biology. Vol. 34. 2004. p. 183-194. (Advances in Molecular and Cell Biology). https://doi.org/10.1016/S1569-2558(03)34013-5
Sieck, Gary C ; Mantilla, Carlos Bernardo. / Influence of sex hormones on the neuromuscular junction. Advances in Molecular and Cell Biology. Vol. 34 2004. pp. 183-194 (Advances in Molecular and Cell Biology).
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