Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats

Eun Kyung Kim, Hong Kim, Myoung Hwa Lee, Young Sick Kim, Hye Young Yang, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Sam Jun Lee, Hee Hyuk Lee, Mal Soon Shin, Chang Ju Kim

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

During the prenatal period, development of individual is influenced by the environmental factors. In mammals, 5-hydroxytryptamine (5-HT) is a central neurotransmitter that regulates behavioral functions in the vertebrate brain. Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the 5-HT synthesis. Various stresses are known to modulate the 5-HT synthesis and the TPH expression. In the present study, the influence of prenatal noise and music application on the 5-HT synthesis and the TPH expression in the dorsal and median raphe of young rats was investigated. Prenatal noise application increased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. Prenatal music application, in contrast, decreased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. The present study suggests that prenatal stimuli including noise and music may affect the emotional state of offspring.

Original languageEnglish (US)
Pages (from-to)118-129
Number of pages12
JournalNeuroscience Research Communications
Volume35
Issue number2
DOIs
StatePublished - Sep 2004

Keywords

  • 5-Hydroxytryptamine
  • Prenatal noise and music
  • Raphe nuclei

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kim, E. K., Kim, H., Lee, M. H., Kim, Y. S., Yang, H. Y., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lee, S. J., Lee, H. H., Shin, M. S., & Kim, C. J. (2004). Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats. Neuroscience Research Communications, 35(2), 118-129. https://doi.org/10.1002/nrc.20026