Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats

Eun Kyung Kim; Hong Kim; Myoung Hwa Lee; Young Sick Kim; Hye Young Yang; Hyun Kyung Chang; Taeck Hyun Lee; Mi Hyeon Jang; Min Chul Shin; Sam Jun Lee; Hee Hyuk Lee; Mal Soon Shin; Chang Ju Kim

doi:10.1002/nrc.20026

Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats

Eun Kyung Kim, Hong Kim, Myoung Hwa Lee, Young Sick Kim, Hye Young Yang, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Sam Jun Lee, Hee Hyuk Lee, Mal Soon Shin, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

During the prenatal period, development of individual is influenced by the environmental factors. In mammals, 5-hydroxytryptamine (5-HT) is a central neurotransmitter that regulates behavioral functions in the vertebrate brain. Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the 5-HT synthesis. Various stresses are known to modulate the 5-HT synthesis and the TPH expression. In the present study, the influence of prenatal noise and music application on the 5-HT synthesis and the TPH expression in the dorsal and median raphe of young rats was investigated. Prenatal noise application increased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. Prenatal music application, in contrast, decreased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. The present study suggests that prenatal stimuli including noise and music may affect the emotional state of offspring.

Original language	English (US)
Pages (from-to)	118-129
Number of pages	12
Journal	Neuroscience Research Communications
Volume	35
Issue number	2
DOIs	https://doi.org/10.1002/nrc.20026
State	Published - Sep 2004

Keywords

5-Hydroxytryptamine
Prenatal noise and music
Raphe nuclei

ASJC Scopus subject areas

Neuroscience(all)

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10.1002/nrc.20026

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Kim, E. K., Kim, H., Lee, M. H., Kim, Y. S., Yang, H. Y., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lee, S. J., Lee, H. H., Shin, M. S., & Kim, C. J. (2004). Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats. Neuroscience Research Communications, 35(2), 118-129. https://doi.org/10.1002/nrc.20026

Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats. / Kim, Eun Kyung; Kim, Hong; Lee, Myoung Hwa; Kim, Young Sick; Yang, Hye Young; Chang, Hyun Kyung; Lee, Taeck Hyun; Jang, Mi Hyeon; Shin, Min Chul; Lee, Sam Jun; Lee, Hee Hyuk; Shin, Mal Soon; Kim, Chang Ju.

In: Neuroscience Research Communications, Vol. 35, No. 2, 09.2004, p. 118-129.

Research output: Contribution to journal › Article

Kim, EK, Kim, H, Lee, MH, Kim, YS, Yang, HY, Chang, HK, Lee, TH, Jang, MH, Shin, MC, Lee, SJ, Lee, HH, Shin, MS & Kim, CJ 2004, 'Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats', Neuroscience Research Communications, vol. 35, no. 2, pp. 118-129. https://doi.org/10.1002/nrc.20026

Kim, Eun Kyung ; Kim, Hong ; Lee, Myoung Hwa ; Kim, Young Sick ; Yang, Hye Young ; Chang, Hyun Kyung ; Lee, Taeck Hyun ; Jang, Mi Hyeon ; Shin, Min Chul ; Lee, Sam Jun ; Lee, Hee Hyuk ; Shin, Mal Soon ; Kim, Chang Ju. / Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats. In: Neuroscience Research Communications. 2004 ; Vol. 35, No. 2. pp. 118-129.

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abstract = "During the prenatal period, development of individual is influenced by the environmental factors. In mammals, 5-hydroxytryptamine (5-HT) is a central neurotransmitter that regulates behavioral functions in the vertebrate brain. Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the 5-HT synthesis. Various stresses are known to modulate the 5-HT synthesis and the TPH expression. In the present study, the influence of prenatal noise and music application on the 5-HT synthesis and the TPH expression in the dorsal and median raphe of young rats was investigated. Prenatal noise application increased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. Prenatal music application, in contrast, decreased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. The present study suggests that prenatal stimuli including noise and music may affect the emotional state of offspring.",

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AU - Lee, Taeck Hyun

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