Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats

Eun Kyung Kim; Hong Kim; Myoung Hwa Lee; Young Sick Kim; Hye Young Yang; Hyun Kyung Chang; Taeck Hyun Lee; Mi Hyeon Jang; Min Chul Shin; Sam Jun Lee; Hee Hyuk Lee; Mal Soon Shin; Chang Ju Kim

doi:10.1002/nrc.20026

Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats

Eun Kyung Kim, Hong Kim, Myoung Hwa Lee, Young Sick Kim, Hye Young Yang, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Sam Jun Lee, Hee Hyuk Lee, Mal Soon Shin, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

During the prenatal period, development of individual is influenced by the environmental factors. In mammals, 5-hydroxytryptamine (5-HT) is a central neurotransmitter that regulates behavioral functions in the vertebrate brain. Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the 5-HT synthesis. Various stresses are known to modulate the 5-HT synthesis and the TPH expression. In the present study, the influence of prenatal noise and music application on the 5-HT synthesis and the TPH expression in the dorsal and median raphe of young rats was investigated. Prenatal noise application increased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. Prenatal music application, in contrast, decreased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. The present study suggests that prenatal stimuli including noise and music may affect the emotional state of offspring.

Original language	English (US)
Pages (from-to)	118-129
Number of pages	12
Journal	Neuroscience Research Communications
Volume	35
Issue number	2
DOIs	https://doi.org/10.1002/nrc.20026
State	Published - Sep 2004

Keywords

5-Hydroxytryptamine
Prenatal noise and music
Raphe nuclei

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1002/nrc.20026

Cite this

Kim, E. K., Kim, H., Lee, M. H., Kim, Y. S., Yang, H. Y., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lee, S. J., Lee, H. H., Shin, M. S., & Kim, C. J. (2004). Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats. Neuroscience Research Communications, 35(2), 118-129. https://doi.org/10.1002/nrc.20026

Kim, EK, Kim, H, Lee, MH, Kim, YS, Yang, HY, Chang, HK, Lee, TH, Jang, MH, Shin, MC, Lee, SJ, Lee, HH, Shin, MS & Kim, CJ 2004, 'Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats', Neuroscience Research Communications, vol. 35, no. 2, pp. 118-129. https://doi.org/10.1002/nrc.20026

@article{18f0726bd1214c578b4e086b4bc3a29d,

title = "Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats",

abstract = "During the prenatal period, development of individual is influenced by the environmental factors. In mammals, 5-hydroxytryptamine (5-HT) is a central neurotransmitter that regulates behavioral functions in the vertebrate brain. Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the 5-HT synthesis. Various stresses are known to modulate the 5-HT synthesis and the TPH expression. In the present study, the influence of prenatal noise and music application on the 5-HT synthesis and the TPH expression in the dorsal and median raphe of young rats was investigated. Prenatal noise application increased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. Prenatal music application, in contrast, decreased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. The present study suggests that prenatal stimuli including noise and music may affect the emotional state of offspring.",

keywords = "5-Hydroxytryptamine, Prenatal noise and music, Raphe nuclei",

author = "Kim, {Eun Kyung} and Hong Kim and Lee, {Myoung Hwa} and Kim, {Young Sick} and Yang, {Hye Young} and Chang, {Hyun Kyung} and Lee, {Taeck Hyun} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lee, {Sam Jun} and Lee, {Hee Hyuk} and Shin, {Mal Soon} and Kim, {Chang Ju}",

year = "2004",

month = sep,

doi = "10.1002/nrc.20026",

language = "English (US)",

volume = "35",

pages = "118--129",

journal = "Neuroscience Research Communications",

issn = "0893-6609",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats

AU - Kim, Eun Kyung

AU - Kim, Hong

AU - Lee, Myoung Hwa

AU - Kim, Young Sick

AU - Yang, Hye Young

AU - Chang, Hyun Kyung

AU - Lee, Taeck Hyun

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Sam Jun

AU - Lee, Hee Hyuk

AU - Shin, Mal Soon

AU - Kim, Chang Ju

PY - 2004/9

Y1 - 2004/9

N2 - During the prenatal period, development of individual is influenced by the environmental factors. In mammals, 5-hydroxytryptamine (5-HT) is a central neurotransmitter that regulates behavioral functions in the vertebrate brain. Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the 5-HT synthesis. Various stresses are known to modulate the 5-HT synthesis and the TPH expression. In the present study, the influence of prenatal noise and music application on the 5-HT synthesis and the TPH expression in the dorsal and median raphe of young rats was investigated. Prenatal noise application increased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. Prenatal music application, in contrast, decreased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. The present study suggests that prenatal stimuli including noise and music may affect the emotional state of offspring.

AB - During the prenatal period, development of individual is influenced by the environmental factors. In mammals, 5-hydroxytryptamine (5-HT) is a central neurotransmitter that regulates behavioral functions in the vertebrate brain. Tryptophan hydroxylase (TPH) is a rate-limiting enzyme in the 5-HT synthesis. Various stresses are known to modulate the 5-HT synthesis and the TPH expression. In the present study, the influence of prenatal noise and music application on the 5-HT synthesis and the TPH expression in the dorsal and median raphe of young rats was investigated. Prenatal noise application increased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. Prenatal music application, in contrast, decreased the 5-HT synthesis and the TPH expression in the dorsal and median raphe nuclei of offspring. The present study suggests that prenatal stimuli including noise and music may affect the emotional state of offspring.

KW - 5-Hydroxytryptamine

KW - Prenatal noise and music

KW - Raphe nuclei

UR - http://www.scopus.com/inward/record.url?scp=9144226239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9144226239&partnerID=8YFLogxK

U2 - 10.1002/nrc.20026

DO - 10.1002/nrc.20026

M3 - Article

AN - SCOPUS:9144226239

VL - 35

SP - 118

EP - 129

JO - Neuroscience Research Communications

JF - Neuroscience Research Communications

SN - 0893-6609

IS - 2

ER -

Influence of prenatal noise and music on the 5-hydroxytryptamine synthesis and the tryptophan hydroxylase expression in the raphe nuclei of young rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this