Influence of preeclampsia and late-life hypertension on MRI measures of cortical atrophy

Mekala R. Raman, Nirubol Tosakulwong, Samantha M. Zuk, Matthew L. Senjem, Wendy M. White, Julie A Fields, Michelle M Mielke, Timothy G. Lesnick, Kent R Bailey, Clifford R Jr. Jack, Virginia M Miller, Vesna D Garovic, Kejal M Kantarci

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Objective: Women with a history of preeclampsia are at an increased risk of hypertension and structural brain changes. However, the combined effect of both preeclampsia and late-life hypertension on brain structural changes is not known and was investigated in this study. Methods: Participants were identified from the population-based Rochester Epidemiology Project cohort. Four groups of women were recruited and investigated in this study: first, women with a history of normotensive pregnancy who have late-life hypertension (n=8, median age=62), second, women with a history of normotensive pregnancy who do not have late-life hypertension (n=32, median age=59), third, women with a history of preeclampsia who have late-life hypertension (n=24, median age=60), and fourth, women with a history of preeclampsia who do not have late-life hypertension (n=16, median age=57). Cerebrovascular disease lesions on MRI, and total gray matter volumes were assessed. Results: Total gray matter volumes were smaller in women with a history of preeclampsia and late-life hypertension compared with the other groups. Voxel-based morphometry demonstrated that the volume changes were localized to the posterior brain regions, particularly the occipital lobe gray matter in women with a history of preeclampsia and late-life hypertension. Conclusion: Having late-life hypertension superimposed on a history of preeclampsia affects the brain structure differently than having either a history of preeclampsia alone or a history of normotensive pregnancy either with or without late-life hypertension.

Original languageEnglish (US)
Pages (from-to)2479-2485
Number of pages7
JournalJournal of Hypertension
Volume35
Issue number12
DOIs
StatePublished - Dec 1 2017

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Keywords

  • atrophy
  • cerebrovascular disease
  • hypertension
  • hypertensive pregnancy
  • MRI
  • neuroimaging
  • preeclampsia

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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