TY - JOUR
T1 - Influence of obesity-related risk factors in the aetiology of glioma /631/67/68 /631/67/2324 article
AU - Disney-Hogg, Linden
AU - Sud, Amit
AU - Law, Philip J.
AU - Cornish, Alex J.
AU - Kinnersley, Ben
AU - Ostrom, Quinn T.
AU - Labreche, Karim
AU - Eckel-Passow, Jeanette E.
AU - Armstrong, Georgina N.
AU - Claus, Elizabeth B.
AU - Il'Yasova, Dora
AU - Schildkraut, Joellen
AU - Barnholtz-Sloan, Jill S.
AU - Olson, Sara H.
AU - Bernstein, Jonine L.
AU - Lai, Rose K.
AU - Swerdlow, Anthony J.
AU - Simon, Matthias
AU - Hoffmann, Per
AU - Nöthen, Markus M.
AU - Jöckel, Karl Heinz
AU - Chanock, Stephen
AU - Rajaraman, Preetha
AU - Johansen, Christoffer
AU - Jenkins, Robert B.
AU - Melin, Beatrice S.
AU - Wrensch, Margaret R.
AU - Sanson, Marc
AU - Bondy, Melissa L.
AU - Houlston, Richard S.
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. Methods: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. Results: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. Conclusions: This study provides no evidence to implicate obesity-related factors as causes of glioma.
AB - Background: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. Methods: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. Results: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. Conclusions: This study provides no evidence to implicate obesity-related factors as causes of glioma.
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U2 - 10.1038/s41416-018-0009-x
DO - 10.1038/s41416-018-0009-x
M3 - Article
C2 - 29531326
AN - SCOPUS:85043501357
SN - 0007-0920
VL - 118
SP - 1020
EP - 1027
JO - British journal of cancer
JF - British journal of cancer
IS - 7
ER -