Influence of obesity-related risk factors in the aetiology of glioma /631/67/68 /631/67/2324 article

Linden Disney-Hogg, Amit Sud, Philip J. Law, Alex J. Cornish, Ben Kinnersley, Quinn T. Ostrom, Karim Labreche, Jeanette E Eckel-Passow, Georgina N. Armstrong, Elizabeth B. Claus, Dora Il'Yasova, Joellen Schildkraut, Jill S. Barnholtz-Sloan, Sara H. Olson, Jonine L. Bernstein, Rose K. Lai, Anthony J. Swerdlow, Matthias Simon, Per Hoffmann, Markus M. NöthenKarl Heinz Jöckel, Stephen Chanock, Preetha Rajaraman, Christoffer Johansen, Robert Brian Jenkins, Beatrice S. Melin, Margaret R. Wrensch, Marc Sanson, Melissa L. Bondy, Richard S. Houlston

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. Methods: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. Results: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. Conclusions: This study provides no evidence to implicate obesity-related factors as causes of glioma.

Original languageEnglish (US)
Pages (from-to)1020-1027
Number of pages8
JournalBritish Journal of Cancer
Volume118
Issue number7
DOIs
StatePublished - Apr 1 2018

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Disney-Hogg, L., Sud, A., Law, P. J., Cornish, A. J., Kinnersley, B., Ostrom, Q. T., Labreche, K., Eckel-Passow, J. E., Armstrong, G. N., Claus, E. B., Il'Yasova, D., Schildkraut, J., Barnholtz-Sloan, J. S., Olson, S. H., Bernstein, J. L., Lai, R. K., Swerdlow, A. J., Simon, M., Hoffmann, P., ... Houlston, R. S. (2018). Influence of obesity-related risk factors in the aetiology of glioma /631/67/68 /631/67/2324 article. British Journal of Cancer, 118(7), 1020-1027. https://doi.org/10.1038/s41416-018-0009-x