Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats

Mi-Hyeon D Jang, Sae Bin Jung, Myoung Hwa Lee, Hong Kim, Sam Jun Lee, Young Je Sim, Hee Hyuk Lee, Eun Kyung Kim, Chang Ju Kim, Hye Sook Shin, Jeongseon Kim, Ee Hwa Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalNeuroscience Letters
Volume378
Issue number1
DOIs
StatePublished - Apr 11 2005
Externally publishedYes

Fingerprint

Hippocampus
Alcohols
Mothers
Alcohol Drinking
Fetus
Central Nervous System
Pregnancy
Therapeutics

Keywords

  • c-Fos
  • Hippocampus
  • Immunohistochemistry
  • Maternal alcohol
  • RT-PCR

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats. / Jang, Mi-Hyeon D; Jung, Sae Bin; Lee, Myoung Hwa; Kim, Hong; Lee, Sam Jun; Sim, Young Je; Lee, Hee Hyuk; Kim, Eun Kyung; Kim, Chang Ju; Shin, Hye Sook; Kim, Jeongseon; Kim, Ee Hwa.

In: Neuroscience Letters, Vol. 378, No. 1, 11.04.2005, p. 44-48.

Research output: Contribution to journalArticle

Jang, M-HD, Jung, SB, Lee, MH, Kim, H, Lee, SJ, Sim, YJ, Lee, HH, Kim, EK, Kim, CJ, Shin, HS, Kim, J & Kim, EH 2005, 'Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats', Neuroscience Letters, vol. 378, no. 1, pp. 44-48. https://doi.org/10.1016/j.neulet.2004.12.009
Jang, Mi-Hyeon D ; Jung, Sae Bin ; Lee, Myoung Hwa ; Kim, Hong ; Lee, Sam Jun ; Sim, Young Je ; Lee, Hee Hyuk ; Kim, Eun Kyung ; Kim, Chang Ju ; Shin, Hye Sook ; Kim, Jeongseon ; Kim, Ee Hwa. / Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats. In: Neuroscience Letters. 2005 ; Vol. 378, No. 1. pp. 44-48.
@article{ebeec597f0e847f5b72f1b738dc0414d,
title = "Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats",
abstract = "Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.",
keywords = "c-Fos, Hippocampus, Immunohistochemistry, Maternal alcohol, RT-PCR",
author = "Jang, {Mi-Hyeon D} and Jung, {Sae Bin} and Lee, {Myoung Hwa} and Hong Kim and Lee, {Sam Jun} and Sim, {Young Je} and Lee, {Hee Hyuk} and Kim, {Eun Kyung} and Kim, {Chang Ju} and Shin, {Hye Sook} and Jeongseon Kim and Kim, {Ee Hwa}",
year = "2005",
month = "4",
day = "11",
doi = "10.1016/j.neulet.2004.12.009",
language = "English (US)",
volume = "378",
pages = "44--48",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats

AU - Jang, Mi-Hyeon D

AU - Jung, Sae Bin

AU - Lee, Myoung Hwa

AU - Kim, Hong

AU - Lee, Sam Jun

AU - Sim, Young Je

AU - Lee, Hee Hyuk

AU - Kim, Eun Kyung

AU - Kim, Chang Ju

AU - Shin, Hye Sook

AU - Kim, Jeongseon

AU - Kim, Ee Hwa

PY - 2005/4/11

Y1 - 2005/4/11

N2 - Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.

AB - Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.

KW - c-Fos

KW - Hippocampus

KW - Immunohistochemistry

KW - Maternal alcohol

KW - RT-PCR

UR - http://www.scopus.com/inward/record.url?scp=20044372881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20044372881&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2004.12.009

DO - 10.1016/j.neulet.2004.12.009

M3 - Article

C2 - 15763170

AN - SCOPUS:20044372881

VL - 378

SP - 44

EP - 48

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -