Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats

Mi Hyeon Jang, Sae Bin Jung, Myoung Hwa Lee, Hong Kim, Sam Jun Lee, Young Je Sim, Hee Hyuk Lee, Eun Kyung Kim, Chang Ju Kim, Hye Sook Shin, Jeongseon Kim, Ee Hwa Kim

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalNeuroscience Letters
Volume378
Issue number1
DOIs
StatePublished - Apr 11 2005

Keywords

  • Hippocampus
  • Immunohistochemistry
  • Maternal alcohol
  • RT-PCR
  • c-Fos

ASJC Scopus subject areas

  • Neuroscience(all)

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