Influence of magnesium on the secretion and action of parathyroid hormone

K. S. Nair, I. M. Holdaway, M. C. Evans, A. D. Cameron

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The interactions of serum levels of magnesium and parathyroid hormone (PTH) have been studied in a patient with hypomagnesemia and hypocalcemia following intestinal bypass surgery for obesity. When serum magnesium was low serum PTH was not stimulated by hypocalcemia. With correction of magnesium deficiency hypocalcemia was associated with elevation of serum PTH levels. Infusion of exogenous PTH induced a clearly detectable renal response in the presence of hypomagnesemia but the response was diminished when serum magnesium was elevated. In this patient it appears that hypomagnesemia suppressed parathyroid gland activity, leaving the renal action of PTH intact.

Original languageEnglish (US)
Pages (from-to)267-270
Number of pages4
JournalJournal of Endocrinological Investigation: Official Journal of the Italian Society of Endocrinology
Volume2
Issue number3
DOIs
StatePublished - Jul 1979

Keywords

  • PTH
  • calcium
  • magnesium
  • vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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