Influence of H. pylori Infection on gastric motor and sensory function in asymptomatic volunteers

Stuart B. Saslow, Miriam Thumshirn, Michael Camilleri, G. Richard Locke, George M. Thomforde, Duane D. Burton, Russell B. Hanson

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

The effect of H. pylori infection on gastric motility and sensation is unclear. Our hypothesis is that H. pylori infection increases gastric sensation and reduces gastric accommodation and emptying. In eight H. pylori- positive and eight H. pylori-negative asymptomatic subjects, infection was proven by antral histology or culture. We evaluated: (1) gastric emptying of solids, (2) proximal gastric compliance, (3) fasting and postprandial proximal gastric tone and phasic contractions, (4) gastric sensation during balloon inflations or ingestion of cold water, and (5) abdominal vagal function. H. pylori infection was associated with lower gastric accommodation (median 75% postprandial increase in barostat balloon volume compared to fasting) when compared to the accommodation in uninfected volunteers (median 211% change from fasting). One H. pylori-positive subject had an abnormal abdominal vagal function test and her gastric accommodation response was reduced. Other motor and sensory functions in the two groups were similar. In asymptomatic volunteers, H. pylori infection and gastritis result in reduced accommodation (diastolic dysfunction) but no change in overall sensation or motor functions of the stomach.

Original languageEnglish (US)
Pages (from-to)258-264
Number of pages7
JournalDigestive Diseases and Sciences
Volume43
Issue number2
DOIs
StatePublished - Mar 31 1998

Keywords

  • Gastric accommodation
  • H. pylori
  • Sensation

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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