Influencia del género en la presentación clínica y enfermedades asociadas en adultos con enfermedad celíaca (EC)

Translated title of the contribution: Influence of gender on the clinical presentation and associated diseases in adults with celiac disease

Alberto Rubio Tapia, Claire L. Jansson-Knodell, Mussarat W. Rahim, Jacalyn A. See, Joseph A. Murray

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Introduction: Celiac disease is diagnosed predominantly in women. Objectives: We investigated the influence of gender on (i) age at diagnosis,(ii) clinical manifestations,and (iii) prevalence of associated disorders. Methods: Clinical data were abstracted from the medical record of adults with biopsy-proven celiac disease. Results: The cohort consisted of 385 patients (women,71%). Women were diagnosed at a younger age (women,46.1 years; men,52.6 years; p = 0.001). The prevalence of the following symptoms was higher in women: nausea/vomiting (women,31%; men,16%; p = 0.001),constipation (women,21%; men,10%; p = 0.007),and malaise/fatigue (women,43%; men,33%; p = 0.06). Greasy stools were more prevalent in men (women,11%; men,22%; p = 0.006). Autoimmune diseases were observed in 127 (33%) patients with a female to male ratio of 1.6 (women,37%; men,23%; p = 0.006). Depression,osteoporosis,and fibromyalgia predominated in women. Conclusions: Our findings suggest clinically relevant gender-related differences in celiac disease. These gender differences should be taken into account when managing adult patients with celiac disease.

Translated title of the contributionInfluence of gender on the clinical presentation and associated diseases in adults with celiac disease
Original languageSpanish
Pages (from-to)38-46
Number of pages9
JournalGaceta Medica de Mexico
Volume152
StatePublished - Oct 1 2016

Keywords

  • Antibodies
  • Cancer
  • Celiac disease
  • Mortality
  • Prevalence
  • Serology
  • Sprue

ASJC Scopus subject areas

  • Medicine(all)

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