Introduction: Celiac disease is diagnosed predominantly in women. Objectives: We investigated the influence of gender on (i) age at diagnosis,(ii) clinical manifestations,and (iii) prevalence of associated disorders. Methods: Clinical data were abstracted from the medical record of adults with biopsy-proven celiac disease. Results: The cohort consisted of 385 patients (women,71%). Women were diagnosed at a younger age (women,46.1 years; men,52.6 years; p = 0.001). The prevalence of the following symptoms was higher in women: nausea/vomiting (women,31%; men,16%; p = 0.001),constipation (women,21%; men,10%; p = 0.007),and malaise/fatigue (women,43%; men,33%; p = 0.06). Greasy stools were more prevalent in men (women,11%; men,22%; p = 0.006). Autoimmune diseases were observed in 127 (33%) patients with a female to male ratio of 1.6 (women,37%; men,23%; p = 0.006). Depression,osteoporosis,and fibromyalgia predominated in women. Conclusions: Our findings suggest clinically relevant gender-related differences in celiac disease. These gender differences should be taken into account when managing adult patients with celiac disease.
|Translated title of the contribution||Influence of gender on the clinical presentation and associated diseases in adults with celiac disease|
|Number of pages||9|
|Journal||Gaceta Medica de Mexico|
|State||Published - Oct 1 2016|
- Celiac disease
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