Influence of bronchial blood flow and conductance on pulmonary function in stable systolic heart failure

Maile L. Ceridon, Norman R. Morris, Minelle L. Hulsebus, Thomas P Olson, Sophie Lalande, Bruce David Johnson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The aim of this study was to determine the relationship between airway blood flow (Q̇aw), airway conductance (G f-aw) and pulmonary function in patients with stable HF. Methods: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q̇aw was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔP aw) was estimated from systemic and pulmonary pressure measurements; G f-aw was calculated as Q̇aw/ΔPaw; PF was assessed by spirometry. Results: While Q̇aw was not significantly different between CTRL (61.3±17.9μLmin -1mL -1), HF-A (70.1±26.9μLmin -1mL -1) and HF-B (56.2±14.9μLmin -1mL -1) groups, G f-aw, was elevated in HF-A (1.1±0.4μLmin -1mL -1mmHg -1, p<0.03) and tended to be elevated in HF-B (1.2±0.6μLmin -1mL -1mmHg -1, p=0.07) when compared to CTRL (0.8±0.3μLmin -1mL -1mmHg -1). Significant positive correlations were found between G f-aw and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). Conclusions: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.

Original languageEnglish (US)
Pages (from-to)256-264
Number of pages9
JournalRespiratory Physiology and Neurobiology
Volume177
Issue number3
DOIs
StatePublished - Aug 15 2011

Fingerprint

Systolic Heart Failure
Lung
Pressure
Spirometry
Airway Obstruction
Perfusion
Gases
prednylidene

Keywords

  • Bronchial blood flow
  • Congestion
  • Left ventricular dysfunction

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Influence of bronchial blood flow and conductance on pulmonary function in stable systolic heart failure. / Ceridon, Maile L.; Morris, Norman R.; Hulsebus, Minelle L.; Olson, Thomas P; Lalande, Sophie; Johnson, Bruce David.

In: Respiratory Physiology and Neurobiology, Vol. 177, No. 3, 15.08.2011, p. 256-264.

Research output: Contribution to journalArticle

Ceridon, Maile L. ; Morris, Norman R. ; Hulsebus, Minelle L. ; Olson, Thomas P ; Lalande, Sophie ; Johnson, Bruce David. / Influence of bronchial blood flow and conductance on pulmonary function in stable systolic heart failure. In: Respiratory Physiology and Neurobiology. 2011 ; Vol. 177, No. 3. pp. 256-264.
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abstract = "Background: The aim of this study was to determine the relationship between airway blood flow (Q̇aw), airway conductance (G f-aw) and pulmonary function in patients with stable HF. Methods: 12 controls (CTRL: age=63±9 years, FVC=98±15{\%}pred, LVEF=61±6{\%}) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17{\%}pred, LVEF=28±6{\%}), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12{\%}pred, LVEF=26±6{\%}) were studied. Q̇aw was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔP aw) was estimated from systemic and pulmonary pressure measurements; G f-aw was calculated as Q̇aw/ΔPaw; PF was assessed by spirometry. Results: While Q̇aw was not significantly different between CTRL (61.3±17.9μLmin -1mL -1), HF-A (70.1±26.9μLmin -1mL -1) and HF-B (56.2±14.9μLmin -1mL -1) groups, G f-aw, was elevated in HF-A (1.1±0.4μLmin -1mL -1mmHg -1, p<0.03) and tended to be elevated in HF-B (1.2±0.6μLmin -1mL -1mmHg -1, p=0.07) when compared to CTRL (0.8±0.3μLmin -1mL -1mmHg -1). Significant positive correlations were found between G f-aw and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). Conclusions: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.",
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AU - Ceridon, Maile L.

AU - Morris, Norman R.

AU - Hulsebus, Minelle L.

AU - Olson, Thomas P

AU - Lalande, Sophie

AU - Johnson, Bruce David

PY - 2011/8/15

Y1 - 2011/8/15

N2 - Background: The aim of this study was to determine the relationship between airway blood flow (Q̇aw), airway conductance (G f-aw) and pulmonary function in patients with stable HF. Methods: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q̇aw was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔP aw) was estimated from systemic and pulmonary pressure measurements; G f-aw was calculated as Q̇aw/ΔPaw; PF was assessed by spirometry. Results: While Q̇aw was not significantly different between CTRL (61.3±17.9μLmin -1mL -1), HF-A (70.1±26.9μLmin -1mL -1) and HF-B (56.2±14.9μLmin -1mL -1) groups, G f-aw, was elevated in HF-A (1.1±0.4μLmin -1mL -1mmHg -1, p<0.03) and tended to be elevated in HF-B (1.2±0.6μLmin -1mL -1mmHg -1, p=0.07) when compared to CTRL (0.8±0.3μLmin -1mL -1mmHg -1). Significant positive correlations were found between G f-aw and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). Conclusions: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.

AB - Background: The aim of this study was to determine the relationship between airway blood flow (Q̇aw), airway conductance (G f-aw) and pulmonary function in patients with stable HF. Methods: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q̇aw was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔP aw) was estimated from systemic and pulmonary pressure measurements; G f-aw was calculated as Q̇aw/ΔPaw; PF was assessed by spirometry. Results: While Q̇aw was not significantly different between CTRL (61.3±17.9μLmin -1mL -1), HF-A (70.1±26.9μLmin -1mL -1) and HF-B (56.2±14.9μLmin -1mL -1) groups, G f-aw, was elevated in HF-A (1.1±0.4μLmin -1mL -1mmHg -1, p<0.03) and tended to be elevated in HF-B (1.2±0.6μLmin -1mL -1mmHg -1, p=0.07) when compared to CTRL (0.8±0.3μLmin -1mL -1mmHg -1). Significant positive correlations were found between G f-aw and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). Conclusions: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.

KW - Bronchial blood flow

KW - Congestion

KW - Left ventricular dysfunction

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