Influence of bronchial blood flow and conductance on pulmonary function in stable systolic heart failure

Maile L. Ceridon, Norman R. Morris, Minelle L. Hulsebus, Thomas P. Olson, Sophie Lalande, Bruce D. Johnson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: The aim of this study was to determine the relationship between airway blood flow (Q̇aw), airway conductance (Gf-aw) and pulmonary function in patients with stable HF. Methods: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q̇aw was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔPaw) was estimated from systemic and pulmonary pressure measurements; Gf-aw was calculated as Q̇aw/ΔPaw; PF was assessed by spirometry. Results: While Q̇aw was not significantly different between CTRL (61.3±17.9μLmin-1mL-1), HF-A (70.1±26.9μLmin-1mL-1) and HF-B (56.2±14.9μLmin-1mL-1) groups, Gf-aw, was elevated in HF-A (1.1±0.4μLmin-1mL-1mmHg-1, p<0.03) and tended to be elevated in HF-B (1.2±0.6μLmin-1mL-1mmHg-1, p=0.07) when compared to CTRL (0.8±0.3μLmin-1mL-1mmHg-1). Significant positive correlations were found between Gf-aw and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). Conclusions: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.

Original languageEnglish (US)
Pages (from-to)256-264
Number of pages9
JournalRespiratory Physiology and Neurobiology
Volume177
Issue number3
DOIs
StatePublished - Aug 15 2011

Keywords

  • Bronchial blood flow
  • Congestion
  • Left ventricular dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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