Background: The aim of this study was to determine the relationship between airway blood flow (Q̇aw), airway conductance (Gf-aw) and pulmonary function in patients with stable HF. Methods: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q̇aw was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔPaw) was estimated from systemic and pulmonary pressure measurements; Gf-aw was calculated as Q̇aw/ΔPaw; PF was assessed by spirometry. Results: While Q̇aw was not significantly different between CTRL (61.3±17.9μLmin-1mL-1), HF-A (70.1±26.9μLmin-1mL-1) and HF-B (56.2±14.9μLmin-1mL-1) groups, Gf-aw, was elevated in HF-A (1.1±0.4μLmin-1mL-1mmHg-1, p<0.03) and tended to be elevated in HF-B (1.2±0.6μLmin-1mL-1mmHg-1, p=0.07) when compared to CTRL (0.8±0.3μLmin-1mL-1mmHg-1). Significant positive correlations were found between Gf-aw and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). Conclusions: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.
- Bronchial blood flow
- Left ventricular dysfunction
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine