TY - JOUR
T1 - Influence of bronchial blood flow and conductance on pulmonary function in stable systolic heart failure
AU - Ceridon, Maile L.
AU - Morris, Norman R.
AU - Hulsebus, Minelle L.
AU - Olson, Thomas P.
AU - Lalande, Sophie
AU - Johnson, Bruce D.
N1 - Funding Information:
The authors would like to thank the subjects for their participation in our study and the important contributions of Jennifer Fitz-Gibbon and Dr. Lyle J. Olson in the recruitment and daily testing. We would also like to thank Dr. Kenneth C. Beck for his input regarding this study as well as for his technical expertise and Dr Adam Wanner for his input and guidance in setting up the airway blood flow technique in our laboratory. This study was supported by the National Institute of Health Grant HL71478 and Center for Translational Science Activities Grant Number 1 UL1 RR024150 .
PY - 2011/8/15
Y1 - 2011/8/15
N2 - Background: The aim of this study was to determine the relationship between airway blood flow (Q̇aw), airway conductance (Gf-aw) and pulmonary function in patients with stable HF. Methods: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q̇aw was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔPaw) was estimated from systemic and pulmonary pressure measurements; Gf-aw was calculated as Q̇aw/ΔPaw; PF was assessed by spirometry. Results: While Q̇aw was not significantly different between CTRL (61.3±17.9μLmin-1mL-1), HF-A (70.1±26.9μLmin-1mL-1) and HF-B (56.2±14.9μLmin-1mL-1) groups, Gf-aw, was elevated in HF-A (1.1±0.4μLmin-1mL-1mmHg-1, p<0.03) and tended to be elevated in HF-B (1.2±0.6μLmin-1mL-1mmHg-1, p=0.07) when compared to CTRL (0.8±0.3μLmin-1mL-1mmHg-1). Significant positive correlations were found between Gf-aw and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). Conclusions: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.
AB - Background: The aim of this study was to determine the relationship between airway blood flow (Q̇aw), airway conductance (Gf-aw) and pulmonary function in patients with stable HF. Methods: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q̇aw was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔPaw) was estimated from systemic and pulmonary pressure measurements; Gf-aw was calculated as Q̇aw/ΔPaw; PF was assessed by spirometry. Results: While Q̇aw was not significantly different between CTRL (61.3±17.9μLmin-1mL-1), HF-A (70.1±26.9μLmin-1mL-1) and HF-B (56.2±14.9μLmin-1mL-1) groups, Gf-aw, was elevated in HF-A (1.1±0.4μLmin-1mL-1mmHg-1, p<0.03) and tended to be elevated in HF-B (1.2±0.6μLmin-1mL-1mmHg-1, p=0.07) when compared to CTRL (0.8±0.3μLmin-1mL-1mmHg-1). Significant positive correlations were found between Gf-aw and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). Conclusions: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.
KW - Bronchial blood flow
KW - Congestion
KW - Left ventricular dysfunction
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U2 - 10.1016/j.resp.2011.04.020
DO - 10.1016/j.resp.2011.04.020
M3 - Article
C2 - 21545852
AN - SCOPUS:79959187175
SN - 1569-9048
VL - 177
SP - 256
EP - 264
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 3
ER -