Influence of breast cancer histology on the relationship between ultrasound and pathology tumor size measurements

Bobbi Pritt, Takamaru Ashikaga, Robert G. Oppenheimer, Donald L. Weaver

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Establishing an accurate primary invasive breast cancer size is crucial for patient management. Although ultrasonographic measurement is reported to correlate reliably with the gold standard pathology measurement, few authors have examined the influence of histologic subtype on ultrasound measurement. The common subtypes of invasive breast carcinoma, ductal and lobular, have different growth patterns, which may influence the ability of ultrasound to predict pathologic size. For this analysis, ultrasound and pathology reports were retrospectively reviewed for 204 women with 210 invasive breast cancers, including 129 ductal, 41 lobular, and 40 mixed pattern ductal and lobular carcinomas. For each tumor, the largest pathology and ultrasound dimensions were compared using Pearson's correlations, linear regression, paired t-tests and Wilcoxon signed ranks tests, stratified by histologic subtype. The Hodges-Lehmann approach was used to obtain 95% confidence intervals (CI) for median difference of the sizes. Ultrasonography consistently underestimated pathologic tumor size; the overall median difference was 3.5 mm (CI: 2.5-4.0 mm) and for subtypes: 2.5 mm (CI: 1.5-3.5 mm) for ductal pattern; 3.0 mm (CI: 1.5-4.5 mm) for mixed pattern; and in contrast, 7.5 mm (CI: 5.0-13.5 mm) for lobular pattern tumors. Significant correlations of similar magnitude, were observed between size measurements for ductal, lobular, and mixed subtypes (r=0.816, 0.811 and 0.672, respectively; all P<0.001); however, linear regression models differed between subtypes. Although practical and widely available, ultrasonography tends to underestimate pathologic tumor size. The size difference may be large for lobular carcinomas, potentially influencing stage; differences are less pronounced for ductal and mixed subtypes. Pathologic tumor size can be estimated from the ultrasonographic measurement, particularly if the histologic tumor subtype is known. The results of this study underscore the continued benefit of pretreatment tumor histology.

Original languageEnglish (US)
Pages (from-to)905-910
Number of pages6
JournalModern Pathology
Volume17
Issue number8
DOIs
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

Histology
Pathology
Breast Neoplasms
Confidence Intervals
Neoplasms
Lobular Carcinoma
Linear Models
Ultrasonography
Carcinoma, Ductal, Breast
Ductal Carcinoma
Nonparametric Statistics
Growth

Keywords

  • Breast neoplasms
  • Cancer measurement
  • Cancer staging
  • Comparative studies
  • Pathology
  • Ultrasonography

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Influence of breast cancer histology on the relationship between ultrasound and pathology tumor size measurements. / Pritt, Bobbi; Ashikaga, Takamaru; Oppenheimer, Robert G.; Weaver, Donald L.

In: Modern Pathology, Vol. 17, No. 8, 08.2004, p. 905-910.

Research output: Contribution to journalReview article

Pritt, Bobbi ; Ashikaga, Takamaru ; Oppenheimer, Robert G. ; Weaver, Donald L. / Influence of breast cancer histology on the relationship between ultrasound and pathology tumor size measurements. In: Modern Pathology. 2004 ; Vol. 17, No. 8. pp. 905-910.
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abstract = "Establishing an accurate primary invasive breast cancer size is crucial for patient management. Although ultrasonographic measurement is reported to correlate reliably with the gold standard pathology measurement, few authors have examined the influence of histologic subtype on ultrasound measurement. The common subtypes of invasive breast carcinoma, ductal and lobular, have different growth patterns, which may influence the ability of ultrasound to predict pathologic size. For this analysis, ultrasound and pathology reports were retrospectively reviewed for 204 women with 210 invasive breast cancers, including 129 ductal, 41 lobular, and 40 mixed pattern ductal and lobular carcinomas. For each tumor, the largest pathology and ultrasound dimensions were compared using Pearson's correlations, linear regression, paired t-tests and Wilcoxon signed ranks tests, stratified by histologic subtype. The Hodges-Lehmann approach was used to obtain 95{\%} confidence intervals (CI) for median difference of the sizes. Ultrasonography consistently underestimated pathologic tumor size; the overall median difference was 3.5 mm (CI: 2.5-4.0 mm) and for subtypes: 2.5 mm (CI: 1.5-3.5 mm) for ductal pattern; 3.0 mm (CI: 1.5-4.5 mm) for mixed pattern; and in contrast, 7.5 mm (CI: 5.0-13.5 mm) for lobular pattern tumors. Significant correlations of similar magnitude, were observed between size measurements for ductal, lobular, and mixed subtypes (r=0.816, 0.811 and 0.672, respectively; all P<0.001); however, linear regression models differed between subtypes. Although practical and widely available, ultrasonography tends to underestimate pathologic tumor size. The size difference may be large for lobular carcinomas, potentially influencing stage; differences are less pronounced for ductal and mixed subtypes. Pathologic tumor size can be estimated from the ultrasonographic measurement, particularly if the histologic tumor subtype is known. The results of this study underscore the continued benefit of pretreatment tumor histology.",
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