Influence of body fat distribution on free fatty acid metabolism in obesity

Michael Dennis Jensen, M. W. Haymond, R. A. Rizza, P. E. Cryer, J. M. Miles

Research output: Contribution to journalArticle

479 Citations (Scopus)

Abstract

In order to determine whether differences in body fat distribution result in specific abnormalities of free fatty acid (FFA) metabolism, palmitate turnover, a measure of systemic adipose tissue lipolysis, was measured in 10 women with upper body obesity, 9 women with lower body obesity, and 8 nonobese women under overnight postabsorptive (basal), epinephrine stimulated and insulin suppressed conditions. Results: Upper body obese women had greater (P < 0.005) basal palmitate turnover than lower body obese or nonobese women (2.8 ± 0.2 vs. 2.1 ± 0.2 vs. 1.8 ± 0.2 μmol·kg lean body mass (LBM)-1·min-1, respectively), but a reduced (P < 0.05) net lipolytic response to epinephrine (59 ± 7 vs. 79 ± 5 vs. 81 ± 7 μmol palmitate/kg LBM, respectively). Both types of obesity were associated with impaired suppression of FFA turnover in response to euglycemic hyperinsulinemia compared to non-obese women (P < 0.005). These specific differences in FFA metabolism may reflect adipocyte heterogeneity, which may in turn affect the metabolic abberations associated with different types of obesity. These findings emphasize the need to characterize obese subjects before studies.

Original languageEnglish (US)
Pages (from-to)1168-1173
Number of pages6
JournalJournal of Clinical Investigation
Volume83
Issue number4
StatePublished - 1989

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Body Fat Distribution
Nonesterified Fatty Acids
Obesity
Palmitates
Epinephrine
Lipolysis
Hyperinsulinism
Adipocytes
Adipose Tissue
Insulin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M. (1989). Influence of body fat distribution on free fatty acid metabolism in obesity. Journal of Clinical Investigation, 83(4), 1168-1173.

Influence of body fat distribution on free fatty acid metabolism in obesity. / Jensen, Michael Dennis; Haymond, M. W.; Rizza, R. A.; Cryer, P. E.; Miles, J. M.

In: Journal of Clinical Investigation, Vol. 83, No. 4, 1989, p. 1168-1173.

Research output: Contribution to journalArticle

Jensen, MD, Haymond, MW, Rizza, RA, Cryer, PE & Miles, JM 1989, 'Influence of body fat distribution on free fatty acid metabolism in obesity', Journal of Clinical Investigation, vol. 83, no. 4, pp. 1168-1173.
Jensen, Michael Dennis ; Haymond, M. W. ; Rizza, R. A. ; Cryer, P. E. ; Miles, J. M. / Influence of body fat distribution on free fatty acid metabolism in obesity. In: Journal of Clinical Investigation. 1989 ; Vol. 83, No. 4. pp. 1168-1173.
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