Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy

Jae Kuen Oh, Eric J. Velazquez, Lorenzo Menicanti, Gerald M. Pohost, Robert O. Bonow, Grace D Lin, Anne S. Hellkamp, Paolo Ferrazzi, Stanislaw Wos, Vivek Rao, Daniel Berman, Andrzej Bochenek, Alexander Cherniavsky, Jan Rogowski, Jean L. Rouleau, Kerry L. Lee

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38 Scopus citations

Abstract

Aims The Surgical Treatment for Ischemic Heart Failure (STICH) trial demonstrated no overall benefit when surgical ventricular reconstruction (SVR) was added to coronary artery bypass grafting (CABG) in patients with ischaemic cardiomyopathy. The present analysis was to determine whether, based on baseline left ventricular (LV) function parameters, any subgroups could be identified that benefited from SVR.Methods and resultsAmong the 1000 patients enrolled, Core Lab measures of baseline LV function with adequate quality were obtained in 710 patients using echocardiography, in 352 using cardiovascular magnetic resonance, and in 344 using radionuclide imaging. The relationship between LV end-systolic volume index (ESVI), end-diastolic volume index, ejection fraction (EF), regional wall motion abnormalities, and outcome were first assessed only by echocardiographic measures, and then by 13 algorithms using a different hierarchy of imaging modalities and their quality. The median ESVI and EF were 78.0 (range: 22.8-283.8) mL/m2 and 28.0%, respectively. Hazard ratios comparing the randomized arms by subgroups of LVESVI and LVEF measured by echocardiography found that patients with smaller ventricles (LVESVI <60 mL/m2) and better LVEF (≥33%) may have benefitted by SVR, while those with larger ventricles (LVESVI >90 mL/m2) and lower LVEF (≤25%) did worse with SVR. Algorithms using all three imaging modalities found a weaker relationship between LV global function and the effects of SVR. The extent of regional wall motion abnormality did not influence the effects of SVR. Conclusion sSubgroup analyses of the STICH trial suggest that patients with less dilated LV and better LVEF may benefit from SVR, while those with larger LV and poorer LVEF may do worse.Clinical Trial Registration #: NCT00023595.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalEuropean Heart Journal
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2013

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Keywords

  • Coronary disease
  • Heart failure
  • STICH
  • Surgical ventricular reconstruction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Oh, J. K., Velazquez, E. J., Menicanti, L., Pohost, G. M., Bonow, R. O., Lin, G. D., Hellkamp, A. S., Ferrazzi, P., Wos, S., Rao, V., Berman, D., Bochenek, A., Cherniavsky, A., Rogowski, J., Rouleau, J. L., & Lee, K. L. (2013). Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy. European Heart Journal, 34(1), 39-47. https://doi.org/10.1093/eurheartj/ehs021