Influence of anatomical location on arterial thrombosis

Krzysztof Karnicki, Erzsebet Komorowicz, David N. Fass, Whyte G. Owen, Robert D. McBane

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Atherosclerosis manifests as a systemic disease with near global involvement of the named segments of the arterial tree. Acute thrombotic arterial occlusion, however, is not equally distributed. To evaluate intra-individual regional differences in arterial thrombogenicity, we compared 111In-platelet deposition in porcine carotid and femoral arteries after a standardized crush injury. Within the unidirectional flow conditions of elastic carotid arteries, platelet deposition was more than 3-fold higher compared with predominantly muscular femoral arteries with triphasic arterial flow. To determine the influence of rheology on platelet deposition after crush injury, carotid arteries were transplanted into the femoral position and compared with the paired native carotid and femoral arteries. Similarly, femoral arteries transposed to the carotid position were compared with the paired native carotid artery. In each of these experiments, arterial transposition to a new anatomic location imparts a predilection for platelet deposition indigenous to the new location. In the controlled environment of two high-shear thrombin-independent and -dependent flow chambers, porcine carotid and femoral arterial substrates were indistinguishable from one another with respect to platelet deposition. Regional differences in arterial hemodynamics may account for substantial differences in thrombosis arising from deep arterial injury.

Original languageEnglish (US)
Pages (from-to)342-347
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume22
Issue number2
DOIs
StatePublished - Feb 18 2002

Keywords

  • Arteries
  • Platelets
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Karnicki, K., Komorowicz, E., Fass, D. N., Owen, W. G., & McBane, R. D. (2002). Influence of anatomical location on arterial thrombosis. Arteriosclerosis, thrombosis, and vascular biology, 22(2), 342-347. https://doi.org/10.1161/hq0202.103999