Inflammatory bowel disease in the setting of autoimmune pancreatitis

Karthik Ravi, Suresh T Chari, Santhi Swaroop Vege, William J. Sandborn, Thomas Christopher Smyrk, Edward Vincent Loftus, Jr

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Background: Despite scattered case reports, the prevalence of inflammatory bowel disease (IBD) in patients with autoimmune pancreatitis (AIP) is unknown. We sought to better characterize the putative association between the conditions. Methods: Medical records of 71 patients meeting accepted criteria for AIP were reviewed to identify those with endoscopic and histological evidence of IBD. Colon samples in patients with both AIP and IBD were immunostained to identify IgG4-positive cells. Results: Four patients with AIP (5.6%) had a diagnosis of IBD: 3 had ulcerative colitis (UC) and 1 had Crohn's disease (CD). The diagnosis of IBD preceded or was simultaneous to that of AIP. Two AIP-UC patients treated for AIP with prednisone had a recurrence of AIP, and 1 required 6-mercaptopurine for long-term corticosteroid-sparing treatment. Two AIP-IBD patients underwent Whipple resections, and 1 had recurrent AIP. All 3 patients with UC presented with pancolitis, and 2 required colectomy. Colon samples from 1 patient with UC and 1 patient with CD were available for review. Increased numbers of IgG4-positive cells (10 per high-power field) were noted on the colon sample from the patient with UC. Conclusions: Almost 6% of patients with proven AIP had a diagnosis of IBD, compared to a prevalence of -0.4%-0.5% in the general population, potentially implying a 12-15-fold increase in risk. Patients with both AIP and IBD may have increased extent and severity of IBD. The finding of IgG4-positive cells on colon biopsy suggests that IBD may represent an extrapancreatic manifestation of AIP.

Original languageEnglish (US)
Pages (from-to)1326-1330
Number of pages5
JournalInflammatory Bowel Diseases
Volume15
Issue number9
DOIs
StatePublished - 2009

Fingerprint

Inflammatory Bowel Diseases
Pancreatitis
Ulcerative Colitis
Colon
Immunoglobulin G
Crohn Disease
6-Mercaptopurine
Colectomy
Prednisone
Medical Records
Adrenal Cortex Hormones
Biopsy
Recurrence

Keywords

  • Autoimmune pancreatitis
  • Crohn's disease
  • Inflammatory bowel disease
  • Risk
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Inflammatory bowel disease in the setting of autoimmune pancreatitis. / Ravi, Karthik; Chari, Suresh T; Vege, Santhi Swaroop; Sandborn, William J.; Smyrk, Thomas Christopher; Loftus, Jr, Edward Vincent.

In: Inflammatory Bowel Diseases, Vol. 15, No. 9, 2009, p. 1326-1330.

Research output: Contribution to journalArticle

Ravi, Karthik ; Chari, Suresh T ; Vege, Santhi Swaroop ; Sandborn, William J. ; Smyrk, Thomas Christopher ; Loftus, Jr, Edward Vincent. / Inflammatory bowel disease in the setting of autoimmune pancreatitis. In: Inflammatory Bowel Diseases. 2009 ; Vol. 15, No. 9. pp. 1326-1330.
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