Inflammatory Bowel Disease. Historical Perspective, Epidemiology, and Risk Factors.

Research output: Contribution to journalReview article

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Inflammatory bowel disease (IBD) describes a group of closely related yet heterogeneous predominantly intestinal disease processes that are a result of an uncontrolled immune mediated inflammatory response. It is estimated that approximately one and a half million persons in North America have IBD. Pathogenesis of IBD involves an uncontrolled immune mediated inflammatory response in genetically predisposed individuals to a still unknown environmental trigger that interacts with the intestinal flora. There continues to be an enormous amount of information emanating from epidemiological studies providing expanded insight into the occurrence, distribution, determinants, and mechanisms of inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)1105-1122
Number of pages18
JournalSurgical Clinics of North America
Issue number6
StatePublished - Jan 1 2015
Externally publishedYes



  • Crohn's disease
  • Epidemiology
  • Historical perspective
  • Inflammatory bowel disease
  • Risk factors
  • Ulcerative colitis

ASJC Scopus subject areas

  • Surgery

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