Inflammatory bowel disease and asthma

A populationdy

Yilma A. Fenta, Natalia Tello, Ji A. Jung, Sang Hwa Urm, Edward Vincent Loftus, Jr, Barbara P. Yawn, Xujian Li, Young J Juhn

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: A few cross-sectional studies reported an increased risk of inflammatory bowel disease (IBD) among asthmatics. We conducted a population-based, case-control study that applied predetermined criteria for asthma and IBD to determine whether asthma, as a T-helper 2 (Th2) condition, reduces the risk of IBD, a Th1 condition. Methods: This was a population-based, case-control study using criteria-based ascertainment for IBD and asthma. Subjects were all Rochester, Minnesota, residents who had developed IBD between 1964 and 1983 and their age-and gender-matched controls, using 1:1 matching. Controls were randomly selected from the community using the Rochester Epidemiology Project database and confirmed not to have IBD. All cases and controls were merged with the database comprising all Rochester residents with or without asthma between 1964 and 1983. Results: Of the 231 IBD cases, 55% had ulcerative colitis and the remainder had Crohns disease. Of these, 50.4% were male and 98.1% were Caucasians. The mean age at the time of IBD diagnosis was 33.8 years. Four cases (1.7%) had asthma prior to the index date of IBD, whereas two controls (0.9%) had asthma (unadjusted odds ratio [OR]: 3.0, 95% confidence interval [CI]: 0.31"28.84, P = 0.34). Similarly, 16 IBD cases (6.9%) had asthma ever while 12 controls (5.2%) had asthma ever (unadjusted OR: 1.4, 95% CI: 0.62"3.38, P = 0.40). Conclusions: Asthma as a Th2 condition does not reduce the risk of IBD as a Th1 condition. Because of the limitations of our study and others, the association between asthma and IBD needs to be further studied. Inflamm Bowel Dis 2010

Original languageEnglish (US)
Pages (from-to)1957-1962
Number of pages6
JournalInflammatory Bowel Diseases
Volume16
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Inflammatory Bowel Diseases
Asthma
Case-Control Studies
Odds Ratio
Databases
Confidence Intervals
Ulcerative Colitis
Crohn Disease
Population
Epidemiology
Cross-Sectional Studies

Keywords

  • asthma
  • case-control study
  • Crohns disease
  • epidemiology
  • inflammatory bowel disease
  • risk
  • Rochester Epidemiology Project
  • ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Inflammatory bowel disease and asthma : A populationdy. / Fenta, Yilma A.; Tello, Natalia; Jung, Ji A.; Urm, Sang Hwa; Loftus, Jr, Edward Vincent; Yawn, Barbara P.; Li, Xujian; Juhn, Young J.

In: Inflammatory Bowel Diseases, Vol. 16, No. 11, 11.2010, p. 1957-1962.

Research output: Contribution to journalArticle

Fenta, YA, Tello, N, Jung, JA, Urm, SH, Loftus, Jr, EV, Yawn, BP, Li, X & Juhn, YJ 2010, 'Inflammatory bowel disease and asthma: A populationdy', Inflammatory Bowel Diseases, vol. 16, no. 11, pp. 1957-1962. https://doi.org/10.1002/ibd.21277
Fenta, Yilma A. ; Tello, Natalia ; Jung, Ji A. ; Urm, Sang Hwa ; Loftus, Jr, Edward Vincent ; Yawn, Barbara P. ; Li, Xujian ; Juhn, Young J. / Inflammatory bowel disease and asthma : A populationdy. In: Inflammatory Bowel Diseases. 2010 ; Vol. 16, No. 11. pp. 1957-1962.
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AB - Background: A few cross-sectional studies reported an increased risk of inflammatory bowel disease (IBD) among asthmatics. We conducted a population-based, case-control study that applied predetermined criteria for asthma and IBD to determine whether asthma, as a T-helper 2 (Th2) condition, reduces the risk of IBD, a Th1 condition. Methods: This was a population-based, case-control study using criteria-based ascertainment for IBD and asthma. Subjects were all Rochester, Minnesota, residents who had developed IBD between 1964 and 1983 and their age-and gender-matched controls, using 1:1 matching. Controls were randomly selected from the community using the Rochester Epidemiology Project database and confirmed not to have IBD. All cases and controls were merged with the database comprising all Rochester residents with or without asthma between 1964 and 1983. Results: Of the 231 IBD cases, 55% had ulcerative colitis and the remainder had Crohns disease. Of these, 50.4% were male and 98.1% were Caucasians. The mean age at the time of IBD diagnosis was 33.8 years. Four cases (1.7%) had asthma prior to the index date of IBD, whereas two controls (0.9%) had asthma (unadjusted odds ratio [OR]: 3.0, 95% confidence interval [CI]: 0.31"28.84, P = 0.34). Similarly, 16 IBD cases (6.9%) had asthma ever while 12 controls (5.2%) had asthma ever (unadjusted OR: 1.4, 95% CI: 0.62"3.38, P = 0.40). Conclusions: Asthma as a Th2 condition does not reduce the risk of IBD as a Th1 condition. Because of the limitations of our study and others, the association between asthma and IBD needs to be further studied. Inflamm Bowel Dis 2010

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