Inflammatory biomarkers, multi-morbidity, and biologic aging

Jennifer St. Sauver, Walter Rocca, Nathan LeBrasseur, Alanna Chamberlain, Janet Olson, Debra Jacobson, Michaela McGree, Michelle Mielke

Research output: Contribution to journalArticlepeer-review


Objectives: To study the association between multi-morbidity percentiles, which is a measure of clinical aging, and interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α. Methods: Participants 50 to 95 years of age from the Mayo Clinic Study of Aging were assigned age- and sex-specific multi-morbidity percentiles using look-up tables that were reported previously (n = 1646). Percentiles were divided into quintiles for analysis. Plasma IL-6, IL-10, and TNF-α levels were measured in 1595 participants. Median inflammatory marker levels were compared across multi-morbidity quintiles using nonparametric tests. Results: People with higher multi-morbidity percentiles had significantly higher IL-6 and TNF-α levels compared with those with lower multi-morbidity percentiles. Tests for trend across five multi-morbidity quintiles were significant among women for IL-6 and among participants 70 years of age or older for IL-6 and TNF-α. IL-10 was not associated with multi-morbidity percentiles. Conclusions: Multi-morbidity percentiles may be a useful clinical index of biological age for future studies, particularly in women and people 70 years of age and older.

Original languageEnglish (US)
JournalJournal of International Medical Research
Issue number7
StatePublished - Jul 2022


  • Comorbidity
  • clinical aging
  • inflammatory marker
  • interleukin-10
  • interleukin-6
  • multiple chronic conditions
  • tumor necrosis factor-α

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical


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