Inflammation on the mind: Visualizing immunity in the central nervous system

Silvia S. Kang, Dorian B. McGavern

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Abstract

The central nervous system (CNS) is a remarkably complex structure that utilizes electrochemical signaling to coordinate activities throughout the entire body. Because the nervous system contains nonreplicative cells, it is postulated that, through evolutionary pressures, this compartment has acquired specialized mechanisms to limit damage. One potential source of damage comes from our immune system, which has the capacity to survey the CNS and periphery for the presence of foreign material. The immune system is equipped with numerous effector mechanisms and can greatly alter the homeostasis and function of the CNS. Degeneration, autoimmunity, and pathogen infection can all result in acute, and sometimes chronic, inflammation within the CNS. Understanding the specialized functionality of innate and adaptive immune cells within the CNS is critical to the design of more efficacious treatments to mitigate CNS inflammatory conditions. Much of our knowledge of CNS-immune interactions stems from seminal studies that have used static and dynamic imaging approaches to visualize inflammatory cells responding to different CNS conditions. This review will focus on how imaging techniques have elevated our understanding of CNS inflammation as well as the exciting prospects that lie ahead as we begin to pursue investigation of the inflamed CNS in real time.

Original languageEnglish (US)
Title of host publicationVisualizing Immunity
EditorsDorian McGavern, Michael Dustin
Pages227-263
Number of pages37
Edition1
DOIs
StatePublished - Dec 1 2009

Publication series

NameCurrent Topics in Microbiology and Immunology
Number1
Volume334
ISSN (Print)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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  • Cite this

    Kang, S. S., & McGavern, D. B. (2009). Inflammation on the mind: Visualizing immunity in the central nervous system. In D. McGavern, & M. Dustin (Eds.), Visualizing Immunity (1 ed., pp. 227-263). (Current Topics in Microbiology and Immunology; Vol. 334, No. 1). https://doi.org/10.1007/978-3-540-93864-4-10