Infectivity of hepatic allografts with antibodies to hepatitis B virus

S. Forrest Dodson, Samir Issa, Victor Araya, Timothy Gayowski, Antonio Pinna, Bijan Eghtesad, Shunzaboro Iwatsuki, Eduardo Montalvo, Jorge Rakela, John J. Fung

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Background. Since suitable recipients for hepatic allografts from donors with antibodies to hepatitis B virus (HBV) have not been determined, a review of our 7-year experience with donors positive for hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc), or both was undertaken. Methods. Recipients of hepatic allografts from donors with antibodies to HBV were identified by a retrospective review of procurement records and screened for HBV infection. Results. From January 1, 1990, to January 1, 1997, 2578 liver transplants were performed and 140 (5.4%) recipients received an allograft from a donor with antibodies to HBV. Twenty- five of 48 recipients of a hepatic allograft from a donor positive only for anti-HBs were screened and none developed HBV infection. Twenty-five of 41 naive recipients of a hepatic allograft from an anti-HBc positive donor were screened and 18/25 (72%) developed HBV infection. Four of these 18 naive recipients with HBV infection received an allograft from a donor positive for beth anti-HBc and anti-HBs. Seven of 13 anti-HBs-positive recipients of an allograft from an anti-HBc-positive donor were screened and none developed HBV infection. Fifteen of 16 recipients positive only for anti-HBc who received a hepatic allograft from an anti-HBc-positive donor were screened and 2/15 (13%) developed HBV infection. Conclusions. Hepatic allografts from donors positive only for anti-HBs do not transmit HBV infection. Hepatic allografts from anti-HBc-positive donors frequently transmit HBV infection to naive recipients regardless of the donor anti-HBs status, and antiviral prophylaxis may be indicated. Anti-HBs-positive recipients appear resistant to HBV infection after orthotopic liver transplantation with an allograft from an anti-HBc-positive donor. Recipients positive only for anti-HBc infrequently develop HBV infection when transplanted with an allograft from an anti-HBc-positive donor; however, HBV prophylaxis may be justified.

Original languageEnglish (US)
Pages (from-to)1582-1584
Number of pages3
JournalTransplantation
Volume64
Issue number11
DOIs
StatePublished - Dec 15 1997
Externally publishedYes

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Hepatitis B Antibodies
Allografts
Hepatitis B virus
Virus Diseases
Liver
Liver Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Dodson, S. F., Issa, S., Araya, V., Gayowski, T., Pinna, A., Eghtesad, B., ... Fung, J. J. (1997). Infectivity of hepatic allografts with antibodies to hepatitis B virus. Transplantation, 64(11), 1582-1584. https://doi.org/10.1097/00007890-199712150-00013

Infectivity of hepatic allografts with antibodies to hepatitis B virus. / Dodson, S. Forrest; Issa, Samir; Araya, Victor; Gayowski, Timothy; Pinna, Antonio; Eghtesad, Bijan; Iwatsuki, Shunzaboro; Montalvo, Eduardo; Rakela, Jorge; Fung, John J.

In: Transplantation, Vol. 64, No. 11, 15.12.1997, p. 1582-1584.

Research output: Contribution to journalArticle

Dodson, SF, Issa, S, Araya, V, Gayowski, T, Pinna, A, Eghtesad, B, Iwatsuki, S, Montalvo, E, Rakela, J & Fung, JJ 1997, 'Infectivity of hepatic allografts with antibodies to hepatitis B virus', Transplantation, vol. 64, no. 11, pp. 1582-1584. https://doi.org/10.1097/00007890-199712150-00013
Dodson SF, Issa S, Araya V, Gayowski T, Pinna A, Eghtesad B et al. Infectivity of hepatic allografts with antibodies to hepatitis B virus. Transplantation. 1997 Dec 15;64(11):1582-1584. https://doi.org/10.1097/00007890-199712150-00013
Dodson, S. Forrest ; Issa, Samir ; Araya, Victor ; Gayowski, Timothy ; Pinna, Antonio ; Eghtesad, Bijan ; Iwatsuki, Shunzaboro ; Montalvo, Eduardo ; Rakela, Jorge ; Fung, John J. / Infectivity of hepatic allografts with antibodies to hepatitis B virus. In: Transplantation. 1997 ; Vol. 64, No. 11. pp. 1582-1584.
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abstract = "Background. Since suitable recipients for hepatic allografts from donors with antibodies to hepatitis B virus (HBV) have not been determined, a review of our 7-year experience with donors positive for hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc), or both was undertaken. Methods. Recipients of hepatic allografts from donors with antibodies to HBV were identified by a retrospective review of procurement records and screened for HBV infection. Results. From January 1, 1990, to January 1, 1997, 2578 liver transplants were performed and 140 (5.4{\%}) recipients received an allograft from a donor with antibodies to HBV. Twenty- five of 48 recipients of a hepatic allograft from a donor positive only for anti-HBs were screened and none developed HBV infection. Twenty-five of 41 naive recipients of a hepatic allograft from an anti-HBc positive donor were screened and 18/25 (72{\%}) developed HBV infection. Four of these 18 naive recipients with HBV infection received an allograft from a donor positive for beth anti-HBc and anti-HBs. Seven of 13 anti-HBs-positive recipients of an allograft from an anti-HBc-positive donor were screened and none developed HBV infection. Fifteen of 16 recipients positive only for anti-HBc who received a hepatic allograft from an anti-HBc-positive donor were screened and 2/15 (13{\%}) developed HBV infection. Conclusions. Hepatic allografts from donors positive only for anti-HBs do not transmit HBV infection. Hepatic allografts from anti-HBc-positive donors frequently transmit HBV infection to naive recipients regardless of the donor anti-HBs status, and antiviral prophylaxis may be indicated. Anti-HBs-positive recipients appear resistant to HBV infection after orthotopic liver transplantation with an allograft from an anti-HBc-positive donor. Recipients positive only for anti-HBc infrequently develop HBV infection when transplanted with an allograft from an anti-HBc-positive donor; however, HBV prophylaxis may be justified.",
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T1 - Infectivity of hepatic allografts with antibodies to hepatitis B virus

AU - Dodson, S. Forrest

AU - Issa, Samir

AU - Araya, Victor

AU - Gayowski, Timothy

AU - Pinna, Antonio

AU - Eghtesad, Bijan

AU - Iwatsuki, Shunzaboro

AU - Montalvo, Eduardo

AU - Rakela, Jorge

AU - Fung, John J.

PY - 1997/12/15

Y1 - 1997/12/15

N2 - Background. Since suitable recipients for hepatic allografts from donors with antibodies to hepatitis B virus (HBV) have not been determined, a review of our 7-year experience with donors positive for hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc), or both was undertaken. Methods. Recipients of hepatic allografts from donors with antibodies to HBV were identified by a retrospective review of procurement records and screened for HBV infection. Results. From January 1, 1990, to January 1, 1997, 2578 liver transplants were performed and 140 (5.4%) recipients received an allograft from a donor with antibodies to HBV. Twenty- five of 48 recipients of a hepatic allograft from a donor positive only for anti-HBs were screened and none developed HBV infection. Twenty-five of 41 naive recipients of a hepatic allograft from an anti-HBc positive donor were screened and 18/25 (72%) developed HBV infection. Four of these 18 naive recipients with HBV infection received an allograft from a donor positive for beth anti-HBc and anti-HBs. Seven of 13 anti-HBs-positive recipients of an allograft from an anti-HBc-positive donor were screened and none developed HBV infection. Fifteen of 16 recipients positive only for anti-HBc who received a hepatic allograft from an anti-HBc-positive donor were screened and 2/15 (13%) developed HBV infection. Conclusions. Hepatic allografts from donors positive only for anti-HBs do not transmit HBV infection. Hepatic allografts from anti-HBc-positive donors frequently transmit HBV infection to naive recipients regardless of the donor anti-HBs status, and antiviral prophylaxis may be indicated. Anti-HBs-positive recipients appear resistant to HBV infection after orthotopic liver transplantation with an allograft from an anti-HBc-positive donor. Recipients positive only for anti-HBc infrequently develop HBV infection when transplanted with an allograft from an anti-HBc-positive donor; however, HBV prophylaxis may be justified.

AB - Background. Since suitable recipients for hepatic allografts from donors with antibodies to hepatitis B virus (HBV) have not been determined, a review of our 7-year experience with donors positive for hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc), or both was undertaken. Methods. Recipients of hepatic allografts from donors with antibodies to HBV were identified by a retrospective review of procurement records and screened for HBV infection. Results. From January 1, 1990, to January 1, 1997, 2578 liver transplants were performed and 140 (5.4%) recipients received an allograft from a donor with antibodies to HBV. Twenty- five of 48 recipients of a hepatic allograft from a donor positive only for anti-HBs were screened and none developed HBV infection. Twenty-five of 41 naive recipients of a hepatic allograft from an anti-HBc positive donor were screened and 18/25 (72%) developed HBV infection. Four of these 18 naive recipients with HBV infection received an allograft from a donor positive for beth anti-HBc and anti-HBs. Seven of 13 anti-HBs-positive recipients of an allograft from an anti-HBc-positive donor were screened and none developed HBV infection. Fifteen of 16 recipients positive only for anti-HBc who received a hepatic allograft from an anti-HBc-positive donor were screened and 2/15 (13%) developed HBV infection. Conclusions. Hepatic allografts from donors positive only for anti-HBs do not transmit HBV infection. Hepatic allografts from anti-HBc-positive donors frequently transmit HBV infection to naive recipients regardless of the donor anti-HBs status, and antiviral prophylaxis may be indicated. Anti-HBs-positive recipients appear resistant to HBV infection after orthotopic liver transplantation with an allograft from an anti-HBc-positive donor. Recipients positive only for anti-HBc infrequently develop HBV infection when transplanted with an allograft from an anti-HBc-positive donor; however, HBV prophylaxis may be justified.

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