Infective endocarditis due to Propionibacterium species

M. R. Sohail, A. L. Gray, L. M. Baddour, I. M. Tleyjeh, A. Virk

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Propionibacterium species rarely cause infective endocarditis. When identified in blood cultures, they may be inappropriately disregarded as skin flora contaminants. The purpose of this study was to characterize the clinical presentation and management of endocarditis due to Propionibacterium species. All cases of endocarditis due to Propionibacterium species that were treated at the Mayo Clinic, Rochester, USA were retrospectively reviewed, and the English language medical literature was searched for all previously published reports. Seventy cases, which included eight from the Mayo Clinic, were identified (clinical details were available for only 58 cases). The median age of patients was 52 years, and 90% were males. In 79% of the cases, the infection involved prosthetic material (39 prosthetic valves, one left ventricular Teflon patch, one mitral valve ring, one pulmonary artery prosthetic graft, three pacemakers, and one defibrillator). Blood cultures were positive in 62% of cases. All 22 cases with negative blood cultures were microbiologically confirmed by either positive valve tissue cultures (n = 21) or molecular methods (n = 1). Endocarditis was complicated by abscess formation in 36% of cases. The majority (81%) of patients underwent surgery, either for valve replacement and debridement of a cardiac abscess, or removal of an infected device. Crude in-hospital mortality was 16%. The median duration of postoperative antibiotic treatment was 42 days. Patients were commonly treated with a penicillin derivative alone or in combination with gentamicin. On the basis of the above data, it is recommended that infective endocarditis should be strongly suspected when Propionibacterium species are isolated from multiple blood cultures, particularly in the presence of a cardiovascular device.

Original languageEnglish (US)
Pages (from-to)387-394
Number of pages8
JournalClinical Microbiology and Infection
Volume15
Issue number4
DOIs
StatePublished - 2009

Fingerprint

Propionibacterium
Endocarditis
Abscess
Device Removal
Defibrillators
Polytetrafluoroethylene
Debridement
Hospital Mortality
Gentamicins
Mitral Valve
Penicillins
Pulmonary Artery
Language
Anti-Bacterial Agents
Transplants
Equipment and Supplies
Skin
Blood Culture
Infection

Keywords

  • Acne
  • Endocarditis
  • Granulosum
  • Infection
  • Native valve
  • Propionibacterium
  • Prosthetic valve

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Sohail, M. R., Gray, A. L., Baddour, L. M., Tleyjeh, I. M., & Virk, A. (2009). Infective endocarditis due to Propionibacterium species. Clinical Microbiology and Infection, 15(4), 387-394. https://doi.org/10.1111/j.1469-0691.2009.02703.x

Infective endocarditis due to Propionibacterium species. / Sohail, M. R.; Gray, A. L.; Baddour, L. M.; Tleyjeh, I. M.; Virk, A.

In: Clinical Microbiology and Infection, Vol. 15, No. 4, 2009, p. 387-394.

Research output: Contribution to journalArticle

Sohail, MR, Gray, AL, Baddour, LM, Tleyjeh, IM & Virk, A 2009, 'Infective endocarditis due to Propionibacterium species', Clinical Microbiology and Infection, vol. 15, no. 4, pp. 387-394. https://doi.org/10.1111/j.1469-0691.2009.02703.x
Sohail, M. R. ; Gray, A. L. ; Baddour, L. M. ; Tleyjeh, I. M. ; Virk, A. / Infective endocarditis due to Propionibacterium species. In: Clinical Microbiology and Infection. 2009 ; Vol. 15, No. 4. pp. 387-394.
@article{243393f00b3842acb57624e8543e791b,
title = "Infective endocarditis due to Propionibacterium species",
abstract = "Propionibacterium species rarely cause infective endocarditis. When identified in blood cultures, they may be inappropriately disregarded as skin flora contaminants. The purpose of this study was to characterize the clinical presentation and management of endocarditis due to Propionibacterium species. All cases of endocarditis due to Propionibacterium species that were treated at the Mayo Clinic, Rochester, USA were retrospectively reviewed, and the English language medical literature was searched for all previously published reports. Seventy cases, which included eight from the Mayo Clinic, were identified (clinical details were available for only 58 cases). The median age of patients was 52 years, and 90{\%} were males. In 79{\%} of the cases, the infection involved prosthetic material (39 prosthetic valves, one left ventricular Teflon patch, one mitral valve ring, one pulmonary artery prosthetic graft, three pacemakers, and one defibrillator). Blood cultures were positive in 62{\%} of cases. All 22 cases with negative blood cultures were microbiologically confirmed by either positive valve tissue cultures (n = 21) or molecular methods (n = 1). Endocarditis was complicated by abscess formation in 36{\%} of cases. The majority (81{\%}) of patients underwent surgery, either for valve replacement and debridement of a cardiac abscess, or removal of an infected device. Crude in-hospital mortality was 16{\%}. The median duration of postoperative antibiotic treatment was 42 days. Patients were commonly treated with a penicillin derivative alone or in combination with gentamicin. On the basis of the above data, it is recommended that infective endocarditis should be strongly suspected when Propionibacterium species are isolated from multiple blood cultures, particularly in the presence of a cardiovascular device.",
keywords = "Acne, Endocarditis, Granulosum, Infection, Native valve, Propionibacterium, Prosthetic valve",
author = "Sohail, {M. R.} and Gray, {A. L.} and Baddour, {L. M.} and Tleyjeh, {I. M.} and A. Virk",
year = "2009",
doi = "10.1111/j.1469-0691.2009.02703.x",
language = "English (US)",
volume = "15",
pages = "387--394",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Infective endocarditis due to Propionibacterium species

AU - Sohail, M. R.

AU - Gray, A. L.

AU - Baddour, L. M.

AU - Tleyjeh, I. M.

AU - Virk, A.

PY - 2009

Y1 - 2009

N2 - Propionibacterium species rarely cause infective endocarditis. When identified in blood cultures, they may be inappropriately disregarded as skin flora contaminants. The purpose of this study was to characterize the clinical presentation and management of endocarditis due to Propionibacterium species. All cases of endocarditis due to Propionibacterium species that were treated at the Mayo Clinic, Rochester, USA were retrospectively reviewed, and the English language medical literature was searched for all previously published reports. Seventy cases, which included eight from the Mayo Clinic, were identified (clinical details were available for only 58 cases). The median age of patients was 52 years, and 90% were males. In 79% of the cases, the infection involved prosthetic material (39 prosthetic valves, one left ventricular Teflon patch, one mitral valve ring, one pulmonary artery prosthetic graft, three pacemakers, and one defibrillator). Blood cultures were positive in 62% of cases. All 22 cases with negative blood cultures were microbiologically confirmed by either positive valve tissue cultures (n = 21) or molecular methods (n = 1). Endocarditis was complicated by abscess formation in 36% of cases. The majority (81%) of patients underwent surgery, either for valve replacement and debridement of a cardiac abscess, or removal of an infected device. Crude in-hospital mortality was 16%. The median duration of postoperative antibiotic treatment was 42 days. Patients were commonly treated with a penicillin derivative alone or in combination with gentamicin. On the basis of the above data, it is recommended that infective endocarditis should be strongly suspected when Propionibacterium species are isolated from multiple blood cultures, particularly in the presence of a cardiovascular device.

AB - Propionibacterium species rarely cause infective endocarditis. When identified in blood cultures, they may be inappropriately disregarded as skin flora contaminants. The purpose of this study was to characterize the clinical presentation and management of endocarditis due to Propionibacterium species. All cases of endocarditis due to Propionibacterium species that were treated at the Mayo Clinic, Rochester, USA were retrospectively reviewed, and the English language medical literature was searched for all previously published reports. Seventy cases, which included eight from the Mayo Clinic, were identified (clinical details were available for only 58 cases). The median age of patients was 52 years, and 90% were males. In 79% of the cases, the infection involved prosthetic material (39 prosthetic valves, one left ventricular Teflon patch, one mitral valve ring, one pulmonary artery prosthetic graft, three pacemakers, and one defibrillator). Blood cultures were positive in 62% of cases. All 22 cases with negative blood cultures were microbiologically confirmed by either positive valve tissue cultures (n = 21) or molecular methods (n = 1). Endocarditis was complicated by abscess formation in 36% of cases. The majority (81%) of patients underwent surgery, either for valve replacement and debridement of a cardiac abscess, or removal of an infected device. Crude in-hospital mortality was 16%. The median duration of postoperative antibiotic treatment was 42 days. Patients were commonly treated with a penicillin derivative alone or in combination with gentamicin. On the basis of the above data, it is recommended that infective endocarditis should be strongly suspected when Propionibacterium species are isolated from multiple blood cultures, particularly in the presence of a cardiovascular device.

KW - Acne

KW - Endocarditis

KW - Granulosum

KW - Infection

KW - Native valve

KW - Propionibacterium

KW - Prosthetic valve

UR - http://www.scopus.com/inward/record.url?scp=65149083970&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65149083970&partnerID=8YFLogxK

U2 - 10.1111/j.1469-0691.2009.02703.x

DO - 10.1111/j.1469-0691.2009.02703.x

M3 - Article

C2 - 19260876

AN - SCOPUS:65149083970

VL - 15

SP - 387

EP - 394

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 4

ER -