Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL): A cohort study of newly diagnosed cases compared to controls

J. Moreira, K. G. Rabe, James R Cerhan, Neil Elliot Kay, J. W. Wilson, T. G. Call, J. F. Leis, Diane F Jelinek, S. M. Schwager, D. A. Bowen, C. A. Hanson, Susan L Slager, T. D. Shanafelt

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Although the risk of progression from monoclonal B-cell lymphocytosis (MBL) to chronic lymphocytic leukemia (CLL) has been well characterized, it is unknown whether other common complications associated with CLL, such as increased risk of infection, occurs in individuals with MBL. We used the Mayo CLL database to identify cohorts of individuals with newly diagnosed MBL (n=154) or newly diagnosed CLL (n=174) who resided within 50 miles of Mayo Clinic. A cohort of 689 adult patients seen for a general medical examination who resided within 50 miles of Mayo clinic and who enrolled in a case-control study of non-Hodgkin lymphoma (NHL) was used as a comparison cohort. Hospitalization with infection was more common among individuals with MBL (25/154; 16.2%), and CLL (32/174; 18.4%) than controls (18/689; 2.6%). On pooled multivariable Cox proportional hazards analysis of all 1017 patients (controls, MBL and CLL), male sex (hazards ratio (HR)=2.3; P=0.002), major co-morbid health problems (HR=1.7, P=0.04), the presence of CLL (HR=3.2, P<0.001), treatment for progressive CLL (HR=2.4, P=0.001) and the presence of MBL (HR=3.0, P=0.001) were independently associated with risk of hospitalization for infection. These results suggest the risk of serious infection in clinical MBL is substantially greater than the risk of progression requiring treatment.

Original languageEnglish (US)
Pages (from-to)136-141
Number of pages6
JournalLeukemia
Volume27
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Lymphocytosis
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Cohort Studies
Infection
Hospitalization
Sex Ratio
Non-Hodgkin's Lymphoma
Case-Control Studies
Databases
Health
Therapeutics

Keywords

  • chronic lymphocytic leukemia
  • infection
  • monoclonal B-cell lymphocytosis
  • prognosis

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

Cite this

Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL) : A cohort study of newly diagnosed cases compared to controls. / Moreira, J.; Rabe, K. G.; Cerhan, James R; Kay, Neil Elliot; Wilson, J. W.; Call, T. G.; Leis, J. F.; Jelinek, Diane F; Schwager, S. M.; Bowen, D. A.; Hanson, C. A.; Slager, Susan L; Shanafelt, T. D.

In: Leukemia, Vol. 27, No. 1, 01.2013, p. 136-141.

Research output: Contribution to journalArticle

Moreira, J. ; Rabe, K. G. ; Cerhan, James R ; Kay, Neil Elliot ; Wilson, J. W. ; Call, T. G. ; Leis, J. F. ; Jelinek, Diane F ; Schwager, S. M. ; Bowen, D. A. ; Hanson, C. A. ; Slager, Susan L ; Shanafelt, T. D. / Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL) : A cohort study of newly diagnosed cases compared to controls. In: Leukemia. 2013 ; Vol. 27, No. 1. pp. 136-141.
@article{7d3233dbafd9403aaaf1b8c9331f5e44,
title = "Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL): A cohort study of newly diagnosed cases compared to controls",
abstract = "Although the risk of progression from monoclonal B-cell lymphocytosis (MBL) to chronic lymphocytic leukemia (CLL) has been well characterized, it is unknown whether other common complications associated with CLL, such as increased risk of infection, occurs in individuals with MBL. We used the Mayo CLL database to identify cohorts of individuals with newly diagnosed MBL (n=154) or newly diagnosed CLL (n=174) who resided within 50 miles of Mayo Clinic. A cohort of 689 adult patients seen for a general medical examination who resided within 50 miles of Mayo clinic and who enrolled in a case-control study of non-Hodgkin lymphoma (NHL) was used as a comparison cohort. Hospitalization with infection was more common among individuals with MBL (25/154; 16.2{\%}), and CLL (32/174; 18.4{\%}) than controls (18/689; 2.6{\%}). On pooled multivariable Cox proportional hazards analysis of all 1017 patients (controls, MBL and CLL), male sex (hazards ratio (HR)=2.3; P=0.002), major co-morbid health problems (HR=1.7, P=0.04), the presence of CLL (HR=3.2, P<0.001), treatment for progressive CLL (HR=2.4, P=0.001) and the presence of MBL (HR=3.0, P=0.001) were independently associated with risk of hospitalization for infection. These results suggest the risk of serious infection in clinical MBL is substantially greater than the risk of progression requiring treatment.",
keywords = "chronic lymphocytic leukemia, infection, monoclonal B-cell lymphocytosis, prognosis",
author = "J. Moreira and Rabe, {K. G.} and Cerhan, {James R} and Kay, {Neil Elliot} and Wilson, {J. W.} and Call, {T. G.} and Leis, {J. F.} and Jelinek, {Diane F} and Schwager, {S. M.} and Bowen, {D. A.} and Hanson, {C. A.} and Slager, {Susan L} and Shanafelt, {T. D.}",
year = "2013",
month = "1",
doi = "10.1038/leu.2012.187",
language = "English (US)",
volume = "27",
pages = "136--141",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL)

T2 - A cohort study of newly diagnosed cases compared to controls

AU - Moreira, J.

AU - Rabe, K. G.

AU - Cerhan, James R

AU - Kay, Neil Elliot

AU - Wilson, J. W.

AU - Call, T. G.

AU - Leis, J. F.

AU - Jelinek, Diane F

AU - Schwager, S. M.

AU - Bowen, D. A.

AU - Hanson, C. A.

AU - Slager, Susan L

AU - Shanafelt, T. D.

PY - 2013/1

Y1 - 2013/1

N2 - Although the risk of progression from monoclonal B-cell lymphocytosis (MBL) to chronic lymphocytic leukemia (CLL) has been well characterized, it is unknown whether other common complications associated with CLL, such as increased risk of infection, occurs in individuals with MBL. We used the Mayo CLL database to identify cohorts of individuals with newly diagnosed MBL (n=154) or newly diagnosed CLL (n=174) who resided within 50 miles of Mayo Clinic. A cohort of 689 adult patients seen for a general medical examination who resided within 50 miles of Mayo clinic and who enrolled in a case-control study of non-Hodgkin lymphoma (NHL) was used as a comparison cohort. Hospitalization with infection was more common among individuals with MBL (25/154; 16.2%), and CLL (32/174; 18.4%) than controls (18/689; 2.6%). On pooled multivariable Cox proportional hazards analysis of all 1017 patients (controls, MBL and CLL), male sex (hazards ratio (HR)=2.3; P=0.002), major co-morbid health problems (HR=1.7, P=0.04), the presence of CLL (HR=3.2, P<0.001), treatment for progressive CLL (HR=2.4, P=0.001) and the presence of MBL (HR=3.0, P=0.001) were independently associated with risk of hospitalization for infection. These results suggest the risk of serious infection in clinical MBL is substantially greater than the risk of progression requiring treatment.

AB - Although the risk of progression from monoclonal B-cell lymphocytosis (MBL) to chronic lymphocytic leukemia (CLL) has been well characterized, it is unknown whether other common complications associated with CLL, such as increased risk of infection, occurs in individuals with MBL. We used the Mayo CLL database to identify cohorts of individuals with newly diagnosed MBL (n=154) or newly diagnosed CLL (n=174) who resided within 50 miles of Mayo Clinic. A cohort of 689 adult patients seen for a general medical examination who resided within 50 miles of Mayo clinic and who enrolled in a case-control study of non-Hodgkin lymphoma (NHL) was used as a comparison cohort. Hospitalization with infection was more common among individuals with MBL (25/154; 16.2%), and CLL (32/174; 18.4%) than controls (18/689; 2.6%). On pooled multivariable Cox proportional hazards analysis of all 1017 patients (controls, MBL and CLL), male sex (hazards ratio (HR)=2.3; P=0.002), major co-morbid health problems (HR=1.7, P=0.04), the presence of CLL (HR=3.2, P<0.001), treatment for progressive CLL (HR=2.4, P=0.001) and the presence of MBL (HR=3.0, P=0.001) were independently associated with risk of hospitalization for infection. These results suggest the risk of serious infection in clinical MBL is substantially greater than the risk of progression requiring treatment.

KW - chronic lymphocytic leukemia

KW - infection

KW - monoclonal B-cell lymphocytosis

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=84873570544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873570544&partnerID=8YFLogxK

U2 - 10.1038/leu.2012.187

DO - 10.1038/leu.2012.187

M3 - Article

C2 - 22781591

AN - SCOPUS:84873570544

VL - 27

SP - 136

EP - 141

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 1

ER -