Infections associated with irritable bowel syndrome

Sakteesh V. Gurunathan, Madhusudan Grover

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Irritable bowel syndrome (IBS) affects up to 15% of the US population and results in significant morbidity. Intestinal infections are the most commonly identified risk factors for the development of IBS. Various demographic and clinical risk factors have been implicated in the development of postinfection IBS (PI-IBS). However, the molecular mechanisms of PI-IBS are not well understood. Existing literature proposes a role for immune dysregulation, altered barrier function, and microbial factors in the development of PI-IBS. Epidemiologic literature and animal work has also suggested a role for psychological factors in the development and presentation of PI-IBS. Further studies are needed to understand pathogen-specific mechanisms in humans and the role of peripheral and central factors. Currently, no specific therapeutic approaches exist for prevention or treatment of PI-IBS making it critical to discover the molecular signaling and translational mechanisms involved in the pathophysiology of infection-associated IBS.

Original languageEnglish (US)
Title of host publicationGastrointestinal Diseases and Their Associated Infections
PublisherElsevier
Pages85-95
Number of pages11
ISBN (Electronic)9780323548434
ISBN (Print)9780323548441
DOIs
StatePublished - Jan 1 2019

Keywords

  • Functional gastrointestinal disorders
  • Infectious enteritis
  • Irritable bowel syndrome
  • Microbiota
  • Postinfection

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Gurunathan, S. V., & Grover, M. (2019). Infections associated with irritable bowel syndrome. In Gastrointestinal Diseases and Their Associated Infections (pp. 85-95). Elsevier. https://doi.org/10.1016/B978-0-323-54843-4.00007-6