Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: A proposed model for indirect mitogenesis involving autocrine activity

E. B. Leof; J. A. Proper; A. S. Goustin; G. D. Shipley; P. E. DiCorleto; H. L. Moses

doi:10.1073/pnas.83.8.2453

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: A proposed model for indirect mitogenesis involving autocrine activity

E. B. Leof, J. A. Proper, A. S. Goustin, G. D. Shipley, P. E. DiCorleto, H. L. Moses

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

387 Scopus citations

Abstract

Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor β resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDGF-regulated genes (c-fos and c-myc) were stimulated by transforming growth factor β with delayed kinetics relative to that seen in other cell systems with direct PDGF stimulation. A model is proposed in which the monolayer mitogenicity of transforming growth factor β is mediated by the induction of c-sis and PDGF and the subsequent autocrine stimulation of c-fos, c-myc, and other PDGF-inducible genes.

Original language	English (US)
Pages (from-to)	2453-2457
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	83
Issue number	8
DOIs	https://doi.org/10.1073/pnas.83.8.2453
State	Published - 1986

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Leof, E. B., Proper, J. A., Goustin, A. S., Shipley, G. D., DiCorleto, P. E., & Moses, H. L. (1986). Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: A proposed model for indirect mitogenesis involving autocrine activity. Proceedings of the National Academy of Sciences of the United States of America, 83(8), 2453-2457. https://doi.org/10.1073/pnas.83.8.2453

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β : A proposed model for indirect mitogenesis involving autocrine activity. / Leof, E. B.; Proper, J. A.; Goustin, A. S.; Shipley, G. D.; DiCorleto, P. E.; Moses, H. L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 8, 1986, p. 2453-2457.

Research output: Contribution to journal › Article › peer-review

Leof, EB, Proper, JA, Goustin, AS, Shipley, GD, DiCorleto, PE & Moses, HL 1986, 'Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: A proposed model for indirect mitogenesis involving autocrine activity', Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 8, pp. 2453-2457. https://doi.org/10.1073/pnas.83.8.2453

Leof EB, Proper JA, Goustin AS, Shipley GD, DiCorleto PE, Moses HL. Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: A proposed model for indirect mitogenesis involving autocrine activity. Proceedings of the National Academy of Sciences of the United States of America. 1986;83(8):2453-2457. https://doi.org/10.1073/pnas.83.8.2453

Leof, E. B. ; Proper, J. A. ; Goustin, A. S. ; Shipley, G. D. ; DiCorleto, P. E. ; Moses, H. L. / Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β : A proposed model for indirect mitogenesis involving autocrine activity. In: Proceedings of the National Academy of Sciences of the United States of America. 1986 ; Vol. 83, No. 8. pp. 2453-2457.

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abstract = "Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor β resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDGF-regulated genes (c-fos and c-myc) were stimulated by transforming growth factor β with delayed kinetics relative to that seen in other cell systems with direct PDGF stimulation. A model is proposed in which the monolayer mitogenicity of transforming growth factor β is mediated by the induction of c-sis and PDGF and the subsequent autocrine stimulation of c-fos, c-myc, and other PDGF-inducible genes.",

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AB - Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor β resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDGF-regulated genes (c-fos and c-myc) were stimulated by transforming growth factor β with delayed kinetics relative to that seen in other cell systems with direct PDGF stimulation. A model is proposed in which the monolayer mitogenicity of transforming growth factor β is mediated by the induction of c-sis and PDGF and the subsequent autocrine stimulation of c-fos, c-myc, and other PDGF-inducible genes.

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