Abstract
The authors hypothesized that rapid electrical stimulation can induce nerve sprouting in canine atria, and that LA pacing is more effective than RA pacing in inducing sustained AF. Chronic rapid (20 Hz) LA epicardial pacing was performed in six dogs. Sustained AF (> 48 hours) was induced within 23 ± 8 days, which was much faster than that with RA endocardial pacing using the same protocol (139 ± 84 days, P < 0.05). Nerves were identified by immunocytochemical techniques. In all dogs, growth-associated protein 43-positive (sprouting) nerve density was highest near the pacing site, and the rapid LA pacing resulted in differential nerve sprouting among the LA, left superior pulmonary vein (LSPV), interatrial septum (IAS), and RA (5521 ± 1496, 3154 ± 2329, 3953 ± 1164, 1559 ± 1077 μm2/mm2, respectively, P = 0.0032). Tyrosine hydroxylase-positive (sympathetic) nerve density were not significantly different among groups (2726 ± 1165, 1586 ± 558, 2156 ± 1741, 1509 ± 1242 μm2/mm2, respectively). The nerves were inhomogeneously distributed. LA epicardial pacing induced sustained AF much faster than RA endocardial pacing and rapid electrical stimulation can induce inhomogeneous nerve sprouting near the pacing site.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2247-2252 |
| Number of pages | 6 |
| Journal | PACE - Pacing and Clinical Electrophysiology |
| Volume | 26 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2003 |
| Externally published | Yes |
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Keywords
- Arrhythmia
- Autonomic
- Fibrillation
- Immunohistochemistry
- Nervous system
- Pacing
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Induction of Atrial Fibrillation and Nerve Sprouting by Prolonged Left Atrial Pacing in Dogs. / Akira, Hamabe; Chang, Che Ming; Zhou, Shengmei; Chou, Chung Chuan; Yi, Johnny; Miyauchi, Yasushi; Okuyama, Yuji; Fishbein, Michael C.; Karagueuzian, Hrayr S.; Chen, Lan S.; Chen, Peng Sheng.
In: PACE - Pacing and Clinical Electrophysiology, Vol. 26, No. 12, 01.12.2003, p. 2247-2252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of Atrial Fibrillation and Nerve Sprouting by Prolonged Left Atrial Pacing in Dogs
AU - Akira, Hamabe
AU - Chang, Che Ming
AU - Zhou, Shengmei
AU - Chou, Chung Chuan
AU - Yi, Johnny
AU - Miyauchi, Yasushi
AU - Okuyama, Yuji
AU - Fishbein, Michael C.
AU - Karagueuzian, Hrayr S.
AU - Chen, Lan S.
AU - Chen, Peng Sheng
PY - 2003/12/1
Y1 - 2003/12/1
N2 - The authors hypothesized that rapid electrical stimulation can induce nerve sprouting in canine atria, and that LA pacing is more effective than RA pacing in inducing sustained AF. Chronic rapid (20 Hz) LA epicardial pacing was performed in six dogs. Sustained AF (> 48 hours) was induced within 23 ± 8 days, which was much faster than that with RA endocardial pacing using the same protocol (139 ± 84 days, P < 0.05). Nerves were identified by immunocytochemical techniques. In all dogs, growth-associated protein 43-positive (sprouting) nerve density was highest near the pacing site, and the rapid LA pacing resulted in differential nerve sprouting among the LA, left superior pulmonary vein (LSPV), interatrial septum (IAS), and RA (5521 ± 1496, 3154 ± 2329, 3953 ± 1164, 1559 ± 1077 μm2/mm2, respectively, P = 0.0032). Tyrosine hydroxylase-positive (sympathetic) nerve density were not significantly different among groups (2726 ± 1165, 1586 ± 558, 2156 ± 1741, 1509 ± 1242 μm2/mm2, respectively). The nerves were inhomogeneously distributed. LA epicardial pacing induced sustained AF much faster than RA endocardial pacing and rapid electrical stimulation can induce inhomogeneous nerve sprouting near the pacing site.
AB - The authors hypothesized that rapid electrical stimulation can induce nerve sprouting in canine atria, and that LA pacing is more effective than RA pacing in inducing sustained AF. Chronic rapid (20 Hz) LA epicardial pacing was performed in six dogs. Sustained AF (> 48 hours) was induced within 23 ± 8 days, which was much faster than that with RA endocardial pacing using the same protocol (139 ± 84 days, P < 0.05). Nerves were identified by immunocytochemical techniques. In all dogs, growth-associated protein 43-positive (sprouting) nerve density was highest near the pacing site, and the rapid LA pacing resulted in differential nerve sprouting among the LA, left superior pulmonary vein (LSPV), interatrial septum (IAS), and RA (5521 ± 1496, 3154 ± 2329, 3953 ± 1164, 1559 ± 1077 μm2/mm2, respectively, P = 0.0032). Tyrosine hydroxylase-positive (sympathetic) nerve density were not significantly different among groups (2726 ± 1165, 1586 ± 558, 2156 ± 1741, 1509 ± 1242 μm2/mm2, respectively). The nerves were inhomogeneously distributed. LA epicardial pacing induced sustained AF much faster than RA endocardial pacing and rapid electrical stimulation can induce inhomogeneous nerve sprouting near the pacing site.
KW - Arrhythmia
KW - Autonomic
KW - Fibrillation
KW - Immunohistochemistry
KW - Nervous system
KW - Pacing
UR - http://www.scopus.com/inward/record.url?scp=0346732036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346732036&partnerID=8YFLogxK
U2 - 10.1111/j.1540-8159.2003.00355.x
DO - 10.1111/j.1540-8159.2003.00355.x
M3 - Article
C2 - 14675008
AN - SCOPUS:0346732036
VL - 26
SP - 2247
EP - 2252
JO - PACE - Pacing and Clinical Electrophysiology
JF - PACE - Pacing and Clinical Electrophysiology
SN - 0147-8389
IS - 12
ER -