Induction of apoptosis by cancer chemotherapy

Scott H. Kaufmann, William C. Earnshaw

Research output: Contribution to journalArticlepeer-review

983 Scopus citations

Abstract

Studies performed over the past five years have demonstrated that there are two major cell-intrinsic pathways for inducing apoptosis, one that begins with ligation of cell surface death receptors and another that involves mitochondrial release of cytochrome c. Several reports have suggested that anticancer drugs kill susceptible cells by inducing expression of death receptor ligands, especially Fas ligand (FasL). Other reports have indicated that chemotherapeutic agents trigger apoptosis by inducing release of cytochrome c from mitochondria. In this review, we describe the two prototypic death pathways, indicate experimental approaches for distinguishing whether chemotherapeutic agents trigger one pathway or the other, summarize current understanding of the role of the two pathways in chemotherapy-induced apoptosis, and discuss the implications of these studies for mechanisms of resistance to chemotherapeutic agents.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalExperimental Cell Research
Volume256
Issue number1
DOIs
StatePublished - Apr 10 2000

ASJC Scopus subject areas

  • Cell Biology

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