Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor

A. A. Pilon, J. J. Lum, J. Sanchez-Dardon, B. N. Phenix, R. Douglas, Andrew David Badley

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information regarding the toxicities of nonnucleoside RT inhibitors (NNRTI). We demonstrate that efavirenz (an NNRTI) induces caspase- and mitochondrion-dependent apoptosis of Jurkat T cells and human peripheral blood mononuclear cells. The clinical relevance of these observations is not yet clear.

Original languageEnglish (US)
Pages (from-to)2687-2691
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number8
DOIs
StatePublished - 2002

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Reverse Transcriptase Inhibitors
HIV-1
efavirenz
Apoptosis
Nucleosides
Caspase Inhibitors
Jurkat Cells
Poisons
Virus Replication
Blood Cells
Mitochondria
T-Lymphocytes
Human immunodeficiency virus 1 reverse transcriptase

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor. / Pilon, A. A.; Lum, J. J.; Sanchez-Dardon, J.; Phenix, B. N.; Douglas, R.; Badley, Andrew David.

In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 8, 2002, p. 2687-2691.

Research output: Contribution to journalArticle

Pilon, A. A. ; Lum, J. J. ; Sanchez-Dardon, J. ; Phenix, B. N. ; Douglas, R. ; Badley, Andrew David. / Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor. In: Antimicrobial Agents and Chemotherapy. 2002 ; Vol. 46, No. 8. pp. 2687-2691.
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