Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor

A. A. Pilon, J. J. Lum, J. Sanchez-Dardon, B. N. Phenix, R. Douglas, A. D. Badley

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information regarding the toxicities of nonnucleoside RT inhibitors (NNRTI). We demonstrate that efavirenz (an NNRTI) induces caspase- and mitochondrion-dependent apoptosis of Jurkat T cells and human peripheral blood mononuclear cells. The clinical relevance of these observations is not yet clear.

Original languageEnglish (US)
Pages (from-to)2687-2691
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number8
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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