Abstract
Induced pluripotent stem (iPS) cell technology offers an unprecedented opportunity to study patient-specific disease. This biotechnology platform enables recapitulation of individualized disease signatures in a dish through differentiation of patient-derived iPS cells. Beyond disease modeling, the in vitro process of differentiation toward genuine patient tissue offers a blueprint to inform disease etiology and molecular pathogenesis. Here, we highlight recent advances in patient-specific cardiac disease modeling and outline the future promise of iPS cell-based disease discovery applications.
Original language | English (US) |
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Pages (from-to) | 773-783 |
Number of pages | 11 |
Journal | Regenerative Medicine |
Volume | 10 |
Issue number | 6 |
DOIs | |
State | Published - Sep 2015 |
Keywords
- cardiomyocyte
- cardiomyopathy
- channelopathy
- disease discovery
- disease modeling
- disease pathogenesis
- induced pluripotent-stem cell
- regenerative medicine
ASJC Scopus subject areas
- Biomedical Engineering
- Embryology