Induced pluripotent stem cells for cardiovascular disease: From product-focused disease modeling to process-focused disease discovery

Katherine A. Campbell, Andre Terzic, Timothy J Nelson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Induced pluripotent stem (iPS) cell technology offers an unprecedented opportunity to study patient-specific disease. This biotechnology platform enables recapitulation of individualized disease signatures in a dish through differentiation of patient-derived iPS cells. Beyond disease modeling, the in vitro process of differentiation toward genuine patient tissue offers a blueprint to inform disease etiology and molecular pathogenesis. Here, we highlight recent advances in patient-specific cardiac disease modeling and outline the future promise of iPS cell-based disease discovery applications.

Original languageEnglish (US)
Pages (from-to)773-783
Number of pages11
JournalRegenerative Medicine
Volume10
Issue number6
DOIs
StatePublished - Sep 1 2015

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Keywords

  • cardiomyocyte
  • cardiomyopathy
  • channelopathy
  • disease discovery
  • disease modeling
  • disease pathogenesis
  • induced pluripotent-stem cell
  • regenerative medicine

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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