Indolent lymphoma

Follicular lymphoma and the microenvironment-insights from gene expression profiling

Lisa Rimsza, Melba C. Jaramillo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

As shown with gene expression profiling (GEP), the development and progression of follicular lymphoma (FL) involves complex interactions between neoplastic B cells and the surrounding microenvironment. GEP further reveals that the tumor microenvironment may predict survival in patients with FL and influence the response to therapy and the risk of transformation. Here, we briefly review GEP technology and summarize the role of the tumor microenvironment in FL diagnosis, prognosis, and transformation. Genes expressed by infiltrating T cells and macrophages appear to be the most important predictors of survival, clinical behavior, and outcome. These findings provide a basis for future studies into the pathogenesis and pathophysiology of FL and may ultimately provide guidance in the choice of therapy and the identification of potential therapeutic targets.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalHematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
Volume2014
Issue number1
DOIs
StatePublished - Dec 5 2014
Externally publishedYes

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Follicular Lymphoma
Gene Expression Profiling
Lymphoma
Tumor Microenvironment
Cellular Microenvironment
Survival
B-Lymphocytes
Therapeutics
Macrophages
Technology
T-Lymphocytes
Genes

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

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