Individuals with scleroderma may have increased risk of sleep-disordered breathing

Brandon T. Nokes, Hassan A. Raza, Rodrigo Cartin-Ceba, Phillip J. Lyng, Lois E. Krahn, Lewis Wesselius, Clinton E. Jokerst, Sarah B. Umar, W. Leroy Griffing, Matthew R. Neville, Atul Malhotra, James M. Parish

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Study Objectives: Scleroderma is associated with abnormal skin thickening, interstitial lung disease, pulmonary hypertension, and abnormalities of the upper airway. These changes can cause cardiopulmonary complications, potentially including sleep-disordered breathing. The objective of this study is to examine the risk of sleep-disordered breathing in patients with scleroderma. Methods:We retrospectively identified patients with documented scleroderma.We abstracted data from their electronic health records, including findings from antibody tests, serial pulmonary function tests, transthoracic echocardiography, high-resolution computed tomography, and overnight forehead oximetry. Results: We identified 171 patients with scleroderma.Mean age at the time of initial consult was 56.5 years (range, 18-96 years), and 150 (86.7%) were women. Scleroderma was categorized as limited disease for 108 (62.4%), diffuse disease for 59 (34.1%), and mixed connective tissue disease for 6 (3.5%). Fifty-four patients (31.2%) had abnormal overnight forehead oximetry results, defined as an oxygen desaturation index greater than 5 or a baseline mean arterial oxygen saturation level less than 90%. Conclusions: Cardiopulmonary complications are common in patients with scleroderma, one of which may be sleep-disordered breathing. In our cohort, approximately one-third of individuals with scleroderma had evidence of sleep-disordered breathing. Moreover, the rate of sleep-disordered breathing in our population of scleroderma patients was twice the rate of pulmonary hypertension and was approximately the same as the rate of interstitial lung disease. Future prospective studies are needed to further assess the role of sleep-disordered breathing in scleroderma clinical outcomes.

Original languageEnglish (US)
Pages (from-to)1665-1669
Number of pages5
JournalJournal of Clinical Sleep Medicine
Volume15
Issue number11
DOIs
StatePublished - Nov 15 2019

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

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    Nokes, B. T., Raza, H. A., Cartin-Ceba, R., Lyng, P. J., Krahn, L. E., Wesselius, L., Jokerst, C. E., Umar, S. B., Griffing, W. L., Neville, M. R., Malhotra, A., & Parish, J. M. (2019). Individuals with scleroderma may have increased risk of sleep-disordered breathing. Journal of Clinical Sleep Medicine, 15(11), 1665-1669. https://doi.org/10.5664/jcsm.8036