Individualized medicine and the microbiome in reproductive tract

Andrea G. Braundmeier, Katherine M. Lenz, Kristin S. Inman, Nicholas D Chia, Patricio Jeraldo, Marina Walther-Antonio, Margret E. Berg Miller, Fang Yang, Douglas J. Creedon, Heidi Nelson, Bryan A. White

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Humans have evolved along with the millions of microorganisms that populate their bodies. These microbes (10<sup>14</sup>) outnumber human cells by 10 to 1 and account for 3 × 10<sup>6</sup> genes, more than ten times the 25,000 human genes. This microbial metagenome acts as our "other genome" and like our own genes, is unique to the individual. Recent international efforts such as the Human Microbiome Project (HMP) and the MetaHIT Project have helped catalog these microbial genomes using culture-independent, high-throughput, next-generation sequencing. This manuscript will describe recent efforts to define microbial diversity in the female reproductive tract because of the impact that microbial function has on reproductive efficiency. In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. Investigations of the human microbiome are propelling interventional strategies from treating medical populations to treating individual patients. In particular, we highlight how understanding and defining microbial community structures in different disease and physiological states have lead to the discovery of biomarkers and, more importantly, the development and implementation of microbial intervention strategies (probiotics) into modern day medicine. Finally this review will conclude with a literature summary of the effectiveness of microbial intervention strategies that have been implemented in animal and human models of disease and the potential for integrating these microbial intervention strategies into standard clinical practice.

Original languageEnglish (US)
Article number97
JournalFrontiers in Physiology
Volume6
Issue numberAPR
DOIs
StatePublished - 2015

Fingerprint

Precision Medicine
Microbiota
Reproductive Health
Microbial Genome
Metagenome
Genes
Animal Disease Models
Modern 1601-history
Probiotics
Periodicity
Biomarkers
Genome
Pregnancy
Infection
Population

Keywords

  • Biomarkers
  • Individualized medicine
  • Microbiome
  • Pregnancy
  • Reproductive tract infections

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Individualized medicine and the microbiome in reproductive tract. / Braundmeier, Andrea G.; Lenz, Katherine M.; Inman, Kristin S.; Chia, Nicholas D; Jeraldo, Patricio; Walther-Antonio, Marina; Berg Miller, Margret E.; Yang, Fang; Creedon, Douglas J.; Nelson, Heidi; White, Bryan A.

In: Frontiers in Physiology, Vol. 6, No. APR, 97, 2015.

Research output: Contribution to journalArticle

Braundmeier, AG, Lenz, KM, Inman, KS, Chia, ND, Jeraldo, P, Walther-Antonio, M, Berg Miller, ME, Yang, F, Creedon, DJ, Nelson, H & White, BA 2015, 'Individualized medicine and the microbiome in reproductive tract', Frontiers in Physiology, vol. 6, no. APR, 97. https://doi.org/10.3389/fphys.2015.00097
Braundmeier, Andrea G. ; Lenz, Katherine M. ; Inman, Kristin S. ; Chia, Nicholas D ; Jeraldo, Patricio ; Walther-Antonio, Marina ; Berg Miller, Margret E. ; Yang, Fang ; Creedon, Douglas J. ; Nelson, Heidi ; White, Bryan A. / Individualized medicine and the microbiome in reproductive tract. In: Frontiers in Physiology. 2015 ; Vol. 6, No. APR.
@article{eca0d77124ab49159b606c7edb1416f3,
title = "Individualized medicine and the microbiome in reproductive tract",
abstract = "Humans have evolved along with the millions of microorganisms that populate their bodies. These microbes (1014) outnumber human cells by 10 to 1 and account for 3 × 106 genes, more than ten times the 25,000 human genes. This microbial metagenome acts as our {"}other genome{"} and like our own genes, is unique to the individual. Recent international efforts such as the Human Microbiome Project (HMP) and the MetaHIT Project have helped catalog these microbial genomes using culture-independent, high-throughput, next-generation sequencing. This manuscript will describe recent efforts to define microbial diversity in the female reproductive tract because of the impact that microbial function has on reproductive efficiency. In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. Investigations of the human microbiome are propelling interventional strategies from treating medical populations to treating individual patients. In particular, we highlight how understanding and defining microbial community structures in different disease and physiological states have lead to the discovery of biomarkers and, more importantly, the development and implementation of microbial intervention strategies (probiotics) into modern day medicine. Finally this review will conclude with a literature summary of the effectiveness of microbial intervention strategies that have been implemented in animal and human models of disease and the potential for integrating these microbial intervention strategies into standard clinical practice.",
keywords = "Biomarkers, Individualized medicine, Microbiome, Pregnancy, Reproductive tract infections",
author = "Braundmeier, {Andrea G.} and Lenz, {Katherine M.} and Inman, {Kristin S.} and Chia, {Nicholas D} and Patricio Jeraldo and Marina Walther-Antonio and {Berg Miller}, {Margret E.} and Fang Yang and Creedon, {Douglas J.} and Heidi Nelson and White, {Bryan A.}",
year = "2015",
doi = "10.3389/fphys.2015.00097",
language = "English (US)",
volume = "6",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",
number = "APR",

}

TY - JOUR

T1 - Individualized medicine and the microbiome in reproductive tract

AU - Braundmeier, Andrea G.

AU - Lenz, Katherine M.

AU - Inman, Kristin S.

AU - Chia, Nicholas D

AU - Jeraldo, Patricio

AU - Walther-Antonio, Marina

AU - Berg Miller, Margret E.

AU - Yang, Fang

AU - Creedon, Douglas J.

AU - Nelson, Heidi

AU - White, Bryan A.

PY - 2015

Y1 - 2015

N2 - Humans have evolved along with the millions of microorganisms that populate their bodies. These microbes (1014) outnumber human cells by 10 to 1 and account for 3 × 106 genes, more than ten times the 25,000 human genes. This microbial metagenome acts as our "other genome" and like our own genes, is unique to the individual. Recent international efforts such as the Human Microbiome Project (HMP) and the MetaHIT Project have helped catalog these microbial genomes using culture-independent, high-throughput, next-generation sequencing. This manuscript will describe recent efforts to define microbial diversity in the female reproductive tract because of the impact that microbial function has on reproductive efficiency. In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. Investigations of the human microbiome are propelling interventional strategies from treating medical populations to treating individual patients. In particular, we highlight how understanding and defining microbial community structures in different disease and physiological states have lead to the discovery of biomarkers and, more importantly, the development and implementation of microbial intervention strategies (probiotics) into modern day medicine. Finally this review will conclude with a literature summary of the effectiveness of microbial intervention strategies that have been implemented in animal and human models of disease and the potential for integrating these microbial intervention strategies into standard clinical practice.

AB - Humans have evolved along with the millions of microorganisms that populate their bodies. These microbes (1014) outnumber human cells by 10 to 1 and account for 3 × 106 genes, more than ten times the 25,000 human genes. This microbial metagenome acts as our "other genome" and like our own genes, is unique to the individual. Recent international efforts such as the Human Microbiome Project (HMP) and the MetaHIT Project have helped catalog these microbial genomes using culture-independent, high-throughput, next-generation sequencing. This manuscript will describe recent efforts to define microbial diversity in the female reproductive tract because of the impact that microbial function has on reproductive efficiency. In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. Investigations of the human microbiome are propelling interventional strategies from treating medical populations to treating individual patients. In particular, we highlight how understanding and defining microbial community structures in different disease and physiological states have lead to the discovery of biomarkers and, more importantly, the development and implementation of microbial intervention strategies (probiotics) into modern day medicine. Finally this review will conclude with a literature summary of the effectiveness of microbial intervention strategies that have been implemented in animal and human models of disease and the potential for integrating these microbial intervention strategies into standard clinical practice.

KW - Biomarkers

KW - Individualized medicine

KW - Microbiome

KW - Pregnancy

KW - Reproductive tract infections

UR - http://www.scopus.com/inward/record.url?scp=84930640751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930640751&partnerID=8YFLogxK

U2 - 10.3389/fphys.2015.00097

DO - 10.3389/fphys.2015.00097

M3 - Article

AN - SCOPUS:84930640751

VL - 6

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

IS - APR

M1 - 97

ER -