@article{52b07c867da444be949d4d964e13490f,
title = "Individualized Delay for Abdominal Computed Tomography Angiography Bolus-Tracking Based on Sequential Monitoring: Increased Aortic Contrast Permits Decreased Injection Rate and Lower Iodine Dose",
abstract = "Objective: The aim of this study was to determine if computed tomography (CT) angiography using an individualized transition delay (CTA-ID) would facilitate reductions in injection rate and iodine dose. Methods: The CTA-ID was performed in 20 patients with routine injection rate and iodine dose; 20 patients with injection rate lowered by 1 mL/s; and 40 patients with injection rate lowered by 1 mL/s with 29% less iodine. Routine CTAs in the same or size-matched patients served as controls. Diagnostic image quality and intra-arterial CT numbers were assessed. Results: The median transition delay between aortic threshold and CTA-ID image acquisition was significantly longer than with conventional bolus tracking (mean increase, 13.3 seconds; P < 0.0001), with image quality being the same or better. Intra-arterial CT numbers were 200 Hounsfield units or greater for 80 of 80 CTA-ID, but not for 6 of 49 (12%) internal control or for 11 of 80 (14%) size-matched control patients. Conclusion: The CTA-ID bolus-tracking software alters transition delays to permit diagnostic CTA examinations despite slower injection rate and less iodine.",
keywords = "computed tomography angiography, iodinated contrast, population biological variation, x-ray computed tomography",
author = "Ralf Gutjahr and Fletcher, {Joel G.} and Lee, {Yong S.} and Halaweish, {Ahmed F.} and Vighnesh Suresh and Weber, {Nikkole M.} and Vrtiska, {Terri J.} and Williamson, {Eric E.} and Bernhard Schmidt and McCollough, {Cynthia H.}",
note = "Funding Information: From the *Siemens Healthineers, Forchheim, Germany; †Department of Radiology, Mayo Clinic, Rochester, Minnesota; ‡Siemens Healthineers, Malvern, Pennsylvania; and §University of Minnesota, Minneapolis, Minnesota. Received for publication December 20, 2018; accepted March 29, 2019. Correspondence to: Joel G. Fletcher, MD, Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 (e‐mail: fletcher.joel@mayo.edu). Funding was provided by Mayo Clinic and Siemens Healthineers. Drs. McCollough and Fletcher receive grant support from Siemens Healthineers, which is provided to Mayo Clinic. Dr Ahmed Halaweish, Dr Bernhard Schmidt, and Mr Ralf Gutjahr are employees of Siemens Healthineers. The remaining authors declare no conflict of interest. Copyright {\textcopyright} 2019 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/RCT.0000000000000874 Publisher Copyright: {\textcopyright} 2019 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2019",
month = jul,
day = "1",
doi = "10.1097/RCT.0000000000000874",
language = "English (US)",
volume = "43",
pages = "612--618",
journal = "Journal of Computer Assisted Tomography",
issn = "0363-8715",
publisher = "Lippincott Williams and Wilkins",
number = "4",
}