Indexed Left Ventricular Dimensions Best Predict Survival After Aortic Valve Replacement in Patients With Aortic Valve Regurgitation

Morgan L. Brown, Hartzell V Schaff, Rakesh M. Suri, Li Zhuo, Thoralf M. Sundt, Joseph A. Dearani, Richard C. Daly, Thomas A. Orszulak

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Indications for valve replacement in patients with aortic regurgitation include diminished ejection fraction and increased left ventricular dimensions. Our objective was to examine the effect of preoperative ejection fraction and left ventricular dimensions on survival and return of normal systolic function (ejection fraction ≥ 0.50) after valve replacement for aortic regurgitation. Methods: Between 1996 and 2006, 301 patients had aortic valve replacement for moderate or greater chronic aortic regurgitation, and 29% had concomitant replacement of the ascending aorta. We reviewed clinical and echocardiographic variables as well as late vital status. Results: Patients' mean age was 55.2 ± 16.5 years, and 78% were male. The mean preoperative ejection fraction was 0.56 ± 0.12, the mean left ventricular end-systolic dimension was 43 ± 10 mm, and the mean left ventricular end-diastolic dimension was 63 ± 9 mm. Operative mortality was 1.7%, and survival at 1, 5, and 10 years was 96%, 90%, and 77%, respectively. This was similar to an age- and sex-matched population (p = 0.214). The level of ejection fraction preoperatively did not predict late survival, nor did absolute values for left ventricular end-systolic dimension and end-diastolic dimension. Indexed left ventricular end-systolic dimension and end-diastolic dimension were predictors (p < 0.01) of late survival. Data from late echocardiography were available for 159 patients (56%) at a mean follow-up of 3.3 ± 2.6 years. Preoperative ejection fraction, left ventricular end-systolic dimension, indexed end-systolic dimension, end-diastolic dimension, and indexed end-diastolic dimension were univariately predictive of late ejection fraction. In a multivariate model the only predictor of late normal ejection fraction was a higher preoperative ejection fraction (odds ratio, 2.85; p < 0.001). Conclusions: In patients who received a valve replacement for aortic regurgitation, decreased ejection fraction and increased left ventricular dimensions were not associated with late mortality. However, larger indexed left ventricular systolic and diastolic dimensions were associated with late mortality. Preservation of late ejection fraction is best if the operation is performed in patients with near normal preoperative left ventricular function.

Original languageEnglish (US)
Pages (from-to)1170-1176
Number of pages7
JournalAnnals of Thoracic Surgery
Volume87
Issue number4
DOIs
StatePublished - Apr 2009

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Aortic Valve Insufficiency
Aortic Valve
Survival
Stroke Volume
Mortality
Left Ventricular Function
Echocardiography
Aorta
Odds Ratio
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Indexed Left Ventricular Dimensions Best Predict Survival After Aortic Valve Replacement in Patients With Aortic Valve Regurgitation. / Brown, Morgan L.; Schaff, Hartzell V; Suri, Rakesh M.; Zhuo, Li; Sundt, Thoralf M.; Dearani, Joseph A.; Daly, Richard C.; Orszulak, Thomas A.

In: Annals of Thoracic Surgery, Vol. 87, No. 4, 04.2009, p. 1170-1176.

Research output: Contribution to journalArticle

Brown, Morgan L. ; Schaff, Hartzell V ; Suri, Rakesh M. ; Zhuo, Li ; Sundt, Thoralf M. ; Dearani, Joseph A. ; Daly, Richard C. ; Orszulak, Thomas A. / Indexed Left Ventricular Dimensions Best Predict Survival After Aortic Valve Replacement in Patients With Aortic Valve Regurgitation. In: Annals of Thoracic Surgery. 2009 ; Vol. 87, No. 4. pp. 1170-1176.
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abstract = "Background: Indications for valve replacement in patients with aortic regurgitation include diminished ejection fraction and increased left ventricular dimensions. Our objective was to examine the effect of preoperative ejection fraction and left ventricular dimensions on survival and return of normal systolic function (ejection fraction ≥ 0.50) after valve replacement for aortic regurgitation. Methods: Between 1996 and 2006, 301 patients had aortic valve replacement for moderate or greater chronic aortic regurgitation, and 29{\%} had concomitant replacement of the ascending aorta. We reviewed clinical and echocardiographic variables as well as late vital status. Results: Patients' mean age was 55.2 ± 16.5 years, and 78{\%} were male. The mean preoperative ejection fraction was 0.56 ± 0.12, the mean left ventricular end-systolic dimension was 43 ± 10 mm, and the mean left ventricular end-diastolic dimension was 63 ± 9 mm. Operative mortality was 1.7{\%}, and survival at 1, 5, and 10 years was 96{\%}, 90{\%}, and 77{\%}, respectively. This was similar to an age- and sex-matched population (p = 0.214). The level of ejection fraction preoperatively did not predict late survival, nor did absolute values for left ventricular end-systolic dimension and end-diastolic dimension. Indexed left ventricular end-systolic dimension and end-diastolic dimension were predictors (p < 0.01) of late survival. Data from late echocardiography were available for 159 patients (56{\%}) at a mean follow-up of 3.3 ± 2.6 years. Preoperative ejection fraction, left ventricular end-systolic dimension, indexed end-systolic dimension, end-diastolic dimension, and indexed end-diastolic dimension were univariately predictive of late ejection fraction. In a multivariate model the only predictor of late normal ejection fraction was a higher preoperative ejection fraction (odds ratio, 2.85; p < 0.001). Conclusions: In patients who received a valve replacement for aortic regurgitation, decreased ejection fraction and increased left ventricular dimensions were not associated with late mortality. However, larger indexed left ventricular systolic and diastolic dimensions were associated with late mortality. Preservation of late ejection fraction is best if the operation is performed in patients with near normal preoperative left ventricular function.",
author = "Brown, {Morgan L.} and Schaff, {Hartzell V} and Suri, {Rakesh M.} and Li Zhuo and Sundt, {Thoralf M.} and Dearani, {Joseph A.} and Daly, {Richard C.} and Orszulak, {Thomas A.}",
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T1 - Indexed Left Ventricular Dimensions Best Predict Survival After Aortic Valve Replacement in Patients With Aortic Valve Regurgitation

AU - Brown, Morgan L.

AU - Schaff, Hartzell V

AU - Suri, Rakesh M.

AU - Zhuo, Li

AU - Sundt, Thoralf M.

AU - Dearani, Joseph A.

AU - Daly, Richard C.

AU - Orszulak, Thomas A.

PY - 2009/4

Y1 - 2009/4

N2 - Background: Indications for valve replacement in patients with aortic regurgitation include diminished ejection fraction and increased left ventricular dimensions. Our objective was to examine the effect of preoperative ejection fraction and left ventricular dimensions on survival and return of normal systolic function (ejection fraction ≥ 0.50) after valve replacement for aortic regurgitation. Methods: Between 1996 and 2006, 301 patients had aortic valve replacement for moderate or greater chronic aortic regurgitation, and 29% had concomitant replacement of the ascending aorta. We reviewed clinical and echocardiographic variables as well as late vital status. Results: Patients' mean age was 55.2 ± 16.5 years, and 78% were male. The mean preoperative ejection fraction was 0.56 ± 0.12, the mean left ventricular end-systolic dimension was 43 ± 10 mm, and the mean left ventricular end-diastolic dimension was 63 ± 9 mm. Operative mortality was 1.7%, and survival at 1, 5, and 10 years was 96%, 90%, and 77%, respectively. This was similar to an age- and sex-matched population (p = 0.214). The level of ejection fraction preoperatively did not predict late survival, nor did absolute values for left ventricular end-systolic dimension and end-diastolic dimension. Indexed left ventricular end-systolic dimension and end-diastolic dimension were predictors (p < 0.01) of late survival. Data from late echocardiography were available for 159 patients (56%) at a mean follow-up of 3.3 ± 2.6 years. Preoperative ejection fraction, left ventricular end-systolic dimension, indexed end-systolic dimension, end-diastolic dimension, and indexed end-diastolic dimension were univariately predictive of late ejection fraction. In a multivariate model the only predictor of late normal ejection fraction was a higher preoperative ejection fraction (odds ratio, 2.85; p < 0.001). Conclusions: In patients who received a valve replacement for aortic regurgitation, decreased ejection fraction and increased left ventricular dimensions were not associated with late mortality. However, larger indexed left ventricular systolic and diastolic dimensions were associated with late mortality. Preservation of late ejection fraction is best if the operation is performed in patients with near normal preoperative left ventricular function.

AB - Background: Indications for valve replacement in patients with aortic regurgitation include diminished ejection fraction and increased left ventricular dimensions. Our objective was to examine the effect of preoperative ejection fraction and left ventricular dimensions on survival and return of normal systolic function (ejection fraction ≥ 0.50) after valve replacement for aortic regurgitation. Methods: Between 1996 and 2006, 301 patients had aortic valve replacement for moderate or greater chronic aortic regurgitation, and 29% had concomitant replacement of the ascending aorta. We reviewed clinical and echocardiographic variables as well as late vital status. Results: Patients' mean age was 55.2 ± 16.5 years, and 78% were male. The mean preoperative ejection fraction was 0.56 ± 0.12, the mean left ventricular end-systolic dimension was 43 ± 10 mm, and the mean left ventricular end-diastolic dimension was 63 ± 9 mm. Operative mortality was 1.7%, and survival at 1, 5, and 10 years was 96%, 90%, and 77%, respectively. This was similar to an age- and sex-matched population (p = 0.214). The level of ejection fraction preoperatively did not predict late survival, nor did absolute values for left ventricular end-systolic dimension and end-diastolic dimension. Indexed left ventricular end-systolic dimension and end-diastolic dimension were predictors (p < 0.01) of late survival. Data from late echocardiography were available for 159 patients (56%) at a mean follow-up of 3.3 ± 2.6 years. Preoperative ejection fraction, left ventricular end-systolic dimension, indexed end-systolic dimension, end-diastolic dimension, and indexed end-diastolic dimension were univariately predictive of late ejection fraction. In a multivariate model the only predictor of late normal ejection fraction was a higher preoperative ejection fraction (odds ratio, 2.85; p < 0.001). Conclusions: In patients who received a valve replacement for aortic regurgitation, decreased ejection fraction and increased left ventricular dimensions were not associated with late mortality. However, larger indexed left ventricular systolic and diastolic dimensions were associated with late mortality. Preservation of late ejection fraction is best if the operation is performed in patients with near normal preoperative left ventricular function.

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