Independent Influences of Body Mass and Gastric Volumes on Satiation in Humans

Silvia Delgado-Aros, Filippo Cremonini, Janet E. Castillo, Heather J. Chial, Duane D. Burton, Irene Ferber, Michael Camilleri

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Background & Aims: We assessed the association of body mass and gastric volumes (fasting and postprandial) with satiation and postprandial symptoms. Methods: Healthy obese and nonobese subjects underwent measurement of caloric intake at maximum satiation; postprandial symptoms were measured with visual analogue scales 30 minutes after a meal. Gastric volume during fasting and after 300 mL of Ensure was measured with technetium-99m single-photon emission computed tomography imaging. We used multiple regression analysis to assess the associations among variables. Results: Among 134 participants (81 women and 53 men), the median age was 26 years (range, 12-58 years), and the median body mass index was 24 kg/m2 (range, 17-48 kg/m2). Increased body mass index, but not height, was associated with delayed satiation (P <0.003, adjusted for sex). Overweight and obese subjects ingested, on average, 225 ± 57 more kilocalories (945 ± 239 kJ) at maximum satiation compared with normal weight individuals. Increased fasting gastric volume was not associated with body mass index or height, but it was significantly associated with delayed satiation (P = 0.001, adjusted for body mass index and sex). An increase of 50 mL in the fasting gastric volume was associated with 114 ± 32 kcal (479 ± 134 kJ) more ingested at maximum satiation. Increased body mass index was associated with lower fullness scores 30 minutes after a meal (P = 0.0012, adjusted for sex and volume of Ensure ingested). In contrast, scores of post-prandial bloating and pain were higher with increased body mass index (both P <0.05, adjusted for sex and volume of Ensure ingested). Conclusions: Greater body mass index and fasting gastric volume are associated with reduced satiation. Increased body mass index or height was not associated with greater gastric volumes.

Original languageEnglish (US)
Pages (from-to)432-440
Number of pages9
JournalGastroenterology
Volume126
Issue number2
DOIs
StatePublished - Feb 2004

Fingerprint

Satiation
Stomach
Body Mass Index
Fasting
Meals
Technetium
Energy Intake
Single-Photon Emission-Computed Tomography
Visual Analog Scale
Regression Analysis
Weights and Measures
Pain

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Delgado-Aros, S., Cremonini, F., Castillo, J. E., Chial, H. J., Burton, D. D., Ferber, I., & Camilleri, M. (2004). Independent Influences of Body Mass and Gastric Volumes on Satiation in Humans. Gastroenterology, 126(2), 432-440. https://doi.org/10.1053/j.gastro.2003.11.007

Independent Influences of Body Mass and Gastric Volumes on Satiation in Humans. / Delgado-Aros, Silvia; Cremonini, Filippo; Castillo, Janet E.; Chial, Heather J.; Burton, Duane D.; Ferber, Irene; Camilleri, Michael.

In: Gastroenterology, Vol. 126, No. 2, 02.2004, p. 432-440.

Research output: Contribution to journalArticle

Delgado-Aros, S, Cremonini, F, Castillo, JE, Chial, HJ, Burton, DD, Ferber, I & Camilleri, M 2004, 'Independent Influences of Body Mass and Gastric Volumes on Satiation in Humans', Gastroenterology, vol. 126, no. 2, pp. 432-440. https://doi.org/10.1053/j.gastro.2003.11.007
Delgado-Aros S, Cremonini F, Castillo JE, Chial HJ, Burton DD, Ferber I et al. Independent Influences of Body Mass and Gastric Volumes on Satiation in Humans. Gastroenterology. 2004 Feb;126(2):432-440. https://doi.org/10.1053/j.gastro.2003.11.007
Delgado-Aros, Silvia ; Cremonini, Filippo ; Castillo, Janet E. ; Chial, Heather J. ; Burton, Duane D. ; Ferber, Irene ; Camilleri, Michael. / Independent Influences of Body Mass and Gastric Volumes on Satiation in Humans. In: Gastroenterology. 2004 ; Vol. 126, No. 2. pp. 432-440.
@article{afec1c58b500410e811cccc71cb4b87a,
title = "Independent Influences of Body Mass and Gastric Volumes on Satiation in Humans",
abstract = "Background & Aims: We assessed the association of body mass and gastric volumes (fasting and postprandial) with satiation and postprandial symptoms. Methods: Healthy obese and nonobese subjects underwent measurement of caloric intake at maximum satiation; postprandial symptoms were measured with visual analogue scales 30 minutes after a meal. Gastric volume during fasting and after 300 mL of Ensure was measured with technetium-99m single-photon emission computed tomography imaging. We used multiple regression analysis to assess the associations among variables. Results: Among 134 participants (81 women and 53 men), the median age was 26 years (range, 12-58 years), and the median body mass index was 24 kg/m2 (range, 17-48 kg/m2). Increased body mass index, but not height, was associated with delayed satiation (P <0.003, adjusted for sex). Overweight and obese subjects ingested, on average, 225 ± 57 more kilocalories (945 ± 239 kJ) at maximum satiation compared with normal weight individuals. Increased fasting gastric volume was not associated with body mass index or height, but it was significantly associated with delayed satiation (P = 0.001, adjusted for body mass index and sex). An increase of 50 mL in the fasting gastric volume was associated with 114 ± 32 kcal (479 ± 134 kJ) more ingested at maximum satiation. Increased body mass index was associated with lower fullness scores 30 minutes after a meal (P = 0.0012, adjusted for sex and volume of Ensure ingested). In contrast, scores of post-prandial bloating and pain were higher with increased body mass index (both P <0.05, adjusted for sex and volume of Ensure ingested). Conclusions: Greater body mass index and fasting gastric volume are associated with reduced satiation. Increased body mass index or height was not associated with greater gastric volumes.",
author = "Silvia Delgado-Aros and Filippo Cremonini and Castillo, {Janet E.} and Chial, {Heather J.} and Burton, {Duane D.} and Irene Ferber and Michael Camilleri",
year = "2004",
month = "2",
doi = "10.1053/j.gastro.2003.11.007",
language = "English (US)",
volume = "126",
pages = "432--440",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Independent Influences of Body Mass and Gastric Volumes on Satiation in Humans

AU - Delgado-Aros, Silvia

AU - Cremonini, Filippo

AU - Castillo, Janet E.

AU - Chial, Heather J.

AU - Burton, Duane D.

AU - Ferber, Irene

AU - Camilleri, Michael

PY - 2004/2

Y1 - 2004/2

N2 - Background & Aims: We assessed the association of body mass and gastric volumes (fasting and postprandial) with satiation and postprandial symptoms. Methods: Healthy obese and nonobese subjects underwent measurement of caloric intake at maximum satiation; postprandial symptoms were measured with visual analogue scales 30 minutes after a meal. Gastric volume during fasting and after 300 mL of Ensure was measured with technetium-99m single-photon emission computed tomography imaging. We used multiple regression analysis to assess the associations among variables. Results: Among 134 participants (81 women and 53 men), the median age was 26 years (range, 12-58 years), and the median body mass index was 24 kg/m2 (range, 17-48 kg/m2). Increased body mass index, but not height, was associated with delayed satiation (P <0.003, adjusted for sex). Overweight and obese subjects ingested, on average, 225 ± 57 more kilocalories (945 ± 239 kJ) at maximum satiation compared with normal weight individuals. Increased fasting gastric volume was not associated with body mass index or height, but it was significantly associated with delayed satiation (P = 0.001, adjusted for body mass index and sex). An increase of 50 mL in the fasting gastric volume was associated with 114 ± 32 kcal (479 ± 134 kJ) more ingested at maximum satiation. Increased body mass index was associated with lower fullness scores 30 minutes after a meal (P = 0.0012, adjusted for sex and volume of Ensure ingested). In contrast, scores of post-prandial bloating and pain were higher with increased body mass index (both P <0.05, adjusted for sex and volume of Ensure ingested). Conclusions: Greater body mass index and fasting gastric volume are associated with reduced satiation. Increased body mass index or height was not associated with greater gastric volumes.

AB - Background & Aims: We assessed the association of body mass and gastric volumes (fasting and postprandial) with satiation and postprandial symptoms. Methods: Healthy obese and nonobese subjects underwent measurement of caloric intake at maximum satiation; postprandial symptoms were measured with visual analogue scales 30 minutes after a meal. Gastric volume during fasting and after 300 mL of Ensure was measured with technetium-99m single-photon emission computed tomography imaging. We used multiple regression analysis to assess the associations among variables. Results: Among 134 participants (81 women and 53 men), the median age was 26 years (range, 12-58 years), and the median body mass index was 24 kg/m2 (range, 17-48 kg/m2). Increased body mass index, but not height, was associated with delayed satiation (P <0.003, adjusted for sex). Overweight and obese subjects ingested, on average, 225 ± 57 more kilocalories (945 ± 239 kJ) at maximum satiation compared with normal weight individuals. Increased fasting gastric volume was not associated with body mass index or height, but it was significantly associated with delayed satiation (P = 0.001, adjusted for body mass index and sex). An increase of 50 mL in the fasting gastric volume was associated with 114 ± 32 kcal (479 ± 134 kJ) more ingested at maximum satiation. Increased body mass index was associated with lower fullness scores 30 minutes after a meal (P = 0.0012, adjusted for sex and volume of Ensure ingested). In contrast, scores of post-prandial bloating and pain were higher with increased body mass index (both P <0.05, adjusted for sex and volume of Ensure ingested). Conclusions: Greater body mass index and fasting gastric volume are associated with reduced satiation. Increased body mass index or height was not associated with greater gastric volumes.

UR - http://www.scopus.com/inward/record.url?scp=0842300381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842300381&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2003.11.007

DO - 10.1053/j.gastro.2003.11.007

M3 - Article

C2 - 14762780

AN - SCOPUS:0842300381

VL - 126

SP - 432

EP - 440

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 2

ER -