Independent Association between Plasma Leptin and C-Reactive Protein in Healthy Humans

A. S M Shamsuzzaman, Mikolaj Winnicki, Robert Wolk, Anna Svatikova, Bradley G. Phillips, Diane E. Davison, Peter B. Berger, Virend Somers

Research output: Contribution to journalArticle

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Abstract

Background-C-reactive protein (CRP) is synthesized from the liver and is regulated by cytokines, especially interleukin-6. Leptin, the adipocyte-derived protein product of the ob gene, is related to amount of body fat. The long form of the leptin receptor resembles cytokine receptors, which include the interleukin-6 receptor. Both leptin and CRP may be increased in women, in obesity, and in inflammation, and both have been linked to cardiovascular pathophysiological processes and increased cardiovascular risk. We tested the hypothesis that leptin is associated with CRP levels independently of the influences of gender, body mass index (BMI), waist-to-hip ratio, and other variables. Methods and Results-We studied 100 healthy volunteers (48 men, and 52 women). For all subjects, leptin was independently associated with CRP after adjustment for age, gender, BMI, waist-to-hip ratio, smoking, and alcohol consumption (F=12.39, P=0.0007). There was a strong and significant positive relationship between leptin and CRP in both women (R=0.61, P<0.0001) and men (R=0.55, P<0.0001) considered separately. The association between leptin and CRP was significant even after adjustment for age, BMI, waist-to-hip ratio, smoking, and alcohol consumption in women (F=7.13, P=0.01) and men (F=5.69, P=0.02). When only subjects with BMI <25 kg/m2 were considered (n=47), CRP was not linked to BMI (R=0.02, P=0.96), but a significant association between leptin and CRP was still evident (R=0.55, P<0.0001). Conclusions-Leptin and CRP levels are independently associated in normal humans, providing further evidence linking metabolic and inflammatory cardiovascular disease mechanisms.

Original languageEnglish (US)
Pages (from-to)2181-2185
Number of pages5
JournalCirculation
Volume109
Issue number18
DOIs
StatePublished - May 11 2004

Fingerprint

Leptin
C-Reactive Protein
Body Mass Index
Waist-Hip Ratio
Alcohol Drinking
Smoking
Interleukin-6 Receptors
Leptin Receptors
Cytokine Receptors
Adipocytes
Adipose Tissue
Interleukin-6
Healthy Volunteers
Cardiovascular Diseases
Obesity
Cytokines
Inflammation
Liver

Keywords

  • C-reactive protein
  • Cardiovascular diseases
  • Inflammation
  • Leptin
  • Obesity
  • Risk factors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Shamsuzzaman, A. S. M., Winnicki, M., Wolk, R., Svatikova, A., Phillips, B. G., Davison, D. E., ... Somers, V. (2004). Independent Association between Plasma Leptin and C-Reactive Protein in Healthy Humans. Circulation, 109(18), 2181-2185. https://doi.org/10.1161/01.CIR.0000127960.28627.75

Independent Association between Plasma Leptin and C-Reactive Protein in Healthy Humans. / Shamsuzzaman, A. S M; Winnicki, Mikolaj; Wolk, Robert; Svatikova, Anna; Phillips, Bradley G.; Davison, Diane E.; Berger, Peter B.; Somers, Virend.

In: Circulation, Vol. 109, No. 18, 11.05.2004, p. 2181-2185.

Research output: Contribution to journalArticle

Shamsuzzaman, ASM, Winnicki, M, Wolk, R, Svatikova, A, Phillips, BG, Davison, DE, Berger, PB & Somers, V 2004, 'Independent Association between Plasma Leptin and C-Reactive Protein in Healthy Humans', Circulation, vol. 109, no. 18, pp. 2181-2185. https://doi.org/10.1161/01.CIR.0000127960.28627.75
Shamsuzzaman ASM, Winnicki M, Wolk R, Svatikova A, Phillips BG, Davison DE et al. Independent Association between Plasma Leptin and C-Reactive Protein in Healthy Humans. Circulation. 2004 May 11;109(18):2181-2185. https://doi.org/10.1161/01.CIR.0000127960.28627.75
Shamsuzzaman, A. S M ; Winnicki, Mikolaj ; Wolk, Robert ; Svatikova, Anna ; Phillips, Bradley G. ; Davison, Diane E. ; Berger, Peter B. ; Somers, Virend. / Independent Association between Plasma Leptin and C-Reactive Protein in Healthy Humans. In: Circulation. 2004 ; Vol. 109, No. 18. pp. 2181-2185.
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