Increasing pregnancy-related use of prescribed opioid analgesics

Richard A. Epstein, William V Bobo, Peter R. Martin, James A. Morrow, Wei Wang, Rameela Chandrasekhar, William O. Cooper

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Purpose: To quantify the prevalence of prescribed opioid analgesics among pregnant women enrolled in Tennessee Medicaid from 1995 to2009. Methods: Retrospective cohort study of 277,555 pregnancies identified from birth and fetal death certificates, and linked to previously validated, computerized pharmacy records. Poisson regression was used to estimate trends over time, rate ratios, and 95% confidence intervals (CI). Results: During the study period, 29% of pregnant women filled a prescription for an opioid analgesic. From 1995 to 2009, any pregnancy-related use increased 1.90-fold (95% CI,1.83-1.98), first trimester use increased 2.27-fold (95% CI,2.14-2.41), and second or third trimester use increased 2.02-fold (95% CI,1.93-2.12), after adjusting for maternal characteristics. Any pregnancy-related, first trimester, and second or third trimester use were each more likely among mothers who were at least 21years old, white, non-Hispanic, prima gravid, resided in nonurban areas, enrolled in Medicaid owing to disability, and who had less than a high school education. Conclusions: Opioid analgesic use by Tennessee Medicaid-insured pregnant women increased nearly 2-fold from 1995 to 2009. Additional study is warranted to understand the implications of this increased use.

Original languageEnglish (US)
Pages (from-to)498-503
Number of pages6
JournalAnnals of Epidemiology
Volume23
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Opioid Analgesics
Medicaid
Confidence Intervals
Pregnant Women
Pregnancy
Third Pregnancy Trimester
Second Pregnancy Trimester
First Pregnancy Trimester
Mothers
Death Certificates
Fetal Death
Prescriptions
Cohort Studies
Retrospective Studies
Parturition
Education

Keywords

  • Opioids
  • Pregnancy
  • Prescription

ASJC Scopus subject areas

  • Epidemiology

Cite this

Epstein, R. A., Bobo, W. V., Martin, P. R., Morrow, J. A., Wang, W., Chandrasekhar, R., & Cooper, W. O. (2013). Increasing pregnancy-related use of prescribed opioid analgesics. Annals of Epidemiology, 23(8), 498-503. https://doi.org/10.1016/j.annepidem.2013.05.017

Increasing pregnancy-related use of prescribed opioid analgesics. / Epstein, Richard A.; Bobo, William V; Martin, Peter R.; Morrow, James A.; Wang, Wei; Chandrasekhar, Rameela; Cooper, William O.

In: Annals of Epidemiology, Vol. 23, No. 8, 08.2013, p. 498-503.

Research output: Contribution to journalArticle

Epstein, RA, Bobo, WV, Martin, PR, Morrow, JA, Wang, W, Chandrasekhar, R & Cooper, WO 2013, 'Increasing pregnancy-related use of prescribed opioid analgesics', Annals of Epidemiology, vol. 23, no. 8, pp. 498-503. https://doi.org/10.1016/j.annepidem.2013.05.017
Epstein, Richard A. ; Bobo, William V ; Martin, Peter R. ; Morrow, James A. ; Wang, Wei ; Chandrasekhar, Rameela ; Cooper, William O. / Increasing pregnancy-related use of prescribed opioid analgesics. In: Annals of Epidemiology. 2013 ; Vol. 23, No. 8. pp. 498-503.
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