Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction

Manuel Pera, Alan J. Cameron, Victor F. Trastek, Herschel A. Carpenter, Alan R. Zinsmeister

Research output: Contribution to journalArticle

820 Scopus citations

Abstract

Background: The aim of this study was to determine whether the incidence of adenocarcinoma of the esophagus and esophagogastric junction in a well-defined population was higher than previously recognized. Methods: Clinical records and original histological slides from patients residing in Olmsted County, Minnesota, were reviewed and compared with a previous study in the same population. Results: The incidence of esophageal adenocarcinoma rose from 0.13 for 1935-1971 to 0.74 for 1974-1989, and the incidence of adenocarcinoma of the esophagogastric junction rose from 0.25 to 1.34 per 100,000 personyears. Histological review of preserved surgical specimens showed associated intestinal metaplasia (Barrett's esophagus) in 2 of 2 esophageal and in 5 of 9 esophagogastric adenocarcinomas. Conclusions: The incidence of adenocarcinoma in each location increased five to sixfold compared with the earlier study. This increase could not be explained by improved diagnostic methods or classification changes. The association with Barrett's esophagus and the parallel increased incidence of cancer in each location is evidence that adenocarcinoma of the esophagus and of the esophagogastric junction are related disorders.

Original languageEnglish (US)
Pages (from-to)510-513
Number of pages4
JournalGastroenterology
Volume104
Issue number2
DOIs
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction'. Together they form a unique fingerprint.

  • Cite this

    Pera, M., Cameron, A. J., Trastek, V. F., Carpenter, H. A., & Zinsmeister, A. R. (1993). Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology, 104(2), 510-513. https://doi.org/10.1016/0016-5085(93)90420-H