Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes

Joerg Herrmann, William D. Edwards, David R. Holmes, Kris L. Shogren, Lilach O. Lerman, Aaron Ciechanover, Amir Lerman

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

OBJECTIVES: The current study was designed to examine whether ubiquitin expression is higher in unstable than in stable lesions of patients with acute coronary syndrome (ACS). BACKGROUND: The ubiquitin system has been identified as the nonlysosomal pathway of protein degradation; it is involved in a number of biologic processes crucial to cell and tissue integrity and therefore, might be potentially involved in the rupture of unstable coronary plaques. METHODS: We conducted an autopsy-based study of 25 consecutive patients with fatal ACS. Lesions of both infarct-related and noninfarct-related segments from the same patients were examined for the expression and localization of ubiquitin by use of immunohistochemistry and a semiquantitative grading scale. RESULTS: Ubiquitin immunoreactivity was higher in infarct-related than in noninfarct-related lesions (1.4 ± 0.5 vs. 1.1 ± 0.6, p = 0.03). Compared with areas adjacent to the plaque (0.6 ± 0.7), ubiquitin immunoreactivity was higher in areas around the lipid core (2.5 ± 0.8, p < 0.001), plaque shoulders (1.6 ± 1.1, p < 0.001), and fibrous cap regions (1.6 ± 1.1, p < 0.001). Within the plaque area, co-localization of ubiquitin immunoreactivity with T cells and macrophages was found. In areas adjacent to the plaque, ubiquitin immunoreactivity co-localized with neointima cells and media smooth muscle cells. CONCLUSIONS: In patients with ACS, ubiquitin immunoreactivity is enhanced in unstable, infarct-related lesions, predominantly in plaque regions of tissue degradation. Based on these findings, this study suggests a role for the ubiquitin system in the destabilizadon and rupture of coronary atherosclerotic plaques in humans.

Original languageEnglish (US)
Pages (from-to)1919-1927
Number of pages9
JournalJournal of the American College of Cardiology
Volume40
Issue number11
DOIs
StatePublished - Dec 4 2002

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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