Increased serum N-terminal pro-B-type natriuretic peptide levels in patients with medial arterial calcification and poorly compressible leg arteries

Hayan Jouni, Richard J. Rodeheffer, Iftikhar J. Kullo

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Objective- To determine whether serum levels of N-terminal (NT) pro-B-type natriuretic peptide (pro-BNP) are higher in patients with poorly compressible arteries (PCA) than in patients with peripheral artery disease (PAD) and control subjects without PCA or PAD. Methods and results- Medial arterial calcification in the lower extremities results in PCA and may be associated with increased arterial stiffness and hemodynamic/myocardial stress. PCA was defined as having an ankle-brachial index >1.4 or an ankle blood pressure >255 mm Hg, whereas PAD was defined as having an ankle-brachial index ≤0.9. Study participants with PCA (n=100; aged 71±10 years; 70% men) and age- and sex-matched patients with PAD (n=300) were recruited from the noninvasive vascular laboratory. Age- and sex-matched controls (n=300) were identified from a community-based cohort and had no history of PAD. NT pro-BNP levels were approximately 2.5-fold higher in patients with PCA than in patients with PAD and approximately 4-fold higher than in age- and sex-matched controls. In multivariable regression analyses that adjusted for age, sex, smoking, hypertension, history of coronary heart disease/stroke, systolic blood pressure, and serum creatinine, NT pro-BNP levels remained significantly higher in patients with PCA than in patients with PAD and controls (P<0.001). Conclusion- Patients with medial arterial calcification and PCA have higher serum levels of NT pro-BNP than patients with PAD and controls, which is suggestive of an adverse hemodynamic milieu and increased risk for adverse cardiovascular outcomes.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume31
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • NT pro-BNP
  • arterial stiffness
  • medial arterial calcification
  • natriuretic peptides
  • peripheral artery disease
  • poorly compressible arteries
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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