Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance

Celine M Vachon, Robert A. Kyle, Terry M Therneau, Barbara J. Foreman, Dirk R. Larson, Colin L. Colby, Tara K. Phelps, Angela Dispenzieri, Shaji K Kumar, Jerry A. Katzmann, S Vincent Rajkumar

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

We examined whether monoclonal gammopathy of undetermined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS patients. Probands were recruited from a population-based prevalence study (MGUS) and the Mayo Clinic (MM). Serum samples were collected from first-degree relatives older than 40 years and subjected to electrophoresis and immunofixation. The prevalence of MGUS in relatives was compared with population-based rates. Nine-hundred eleven relatives of 232 MM and 97 MGUS probands were studied. By electrophoresis, MGUS was detected in 55 (6%) relatives, and immunofixation identified 28 additional relatives for an age- and sex-adjusted prevalence of 8.1% (95% CI, 6.3 to 9.8). The prevalence of MGUS in relatives increased with age (1.9%, 6.9%, 11.6%, 14.6%, 21.0% for ages 40-49, 50-59, 60-69, 70-79, ≥ 80 years, respectively; P < .001). Using similar MGUS detection methods, there was a higher risk of MGUS in relatives (age-adjusted risk ratio [RR], 2.6; 95% CI, 1.9 to 3.4) compared with the reference population. The increased risk was seen among relatives of MM(RR, 2.0;95%CI, 1.4 to 2.8) and MGUS probands (RR, 3.3; 95% CI, 2.1 to 4.8). The increased risk of MGUS in first-degree relatives of MGUS or MM patients implies shared environment and/or genetics.

Original languageEnglish (US)
Pages (from-to)785-790
Number of pages6
JournalBlood
Volume114
Issue number4
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Monoclonal Gammopathy of Undetermined Significance
Paraproteinemias
Multiple Myeloma
Electrophoresis
Odds Ratio
Population

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance. / Vachon, Celine M; Kyle, Robert A.; Therneau, Terry M; Foreman, Barbara J.; Larson, Dirk R.; Colby, Colin L.; Phelps, Tara K.; Dispenzieri, Angela; Kumar, Shaji K; Katzmann, Jerry A.; Rajkumar, S Vincent.

In: Blood, Vol. 114, No. 4, 2009, p. 785-790.

Research output: Contribution to journalArticle

@article{bf0c5c77c5fe43be879f4e358f6480c0,
title = "Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance",
abstract = "We examined whether monoclonal gammopathy of undetermined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS patients. Probands were recruited from a population-based prevalence study (MGUS) and the Mayo Clinic (MM). Serum samples were collected from first-degree relatives older than 40 years and subjected to electrophoresis and immunofixation. The prevalence of MGUS in relatives was compared with population-based rates. Nine-hundred eleven relatives of 232 MM and 97 MGUS probands were studied. By electrophoresis, MGUS was detected in 55 (6{\%}) relatives, and immunofixation identified 28 additional relatives for an age- and sex-adjusted prevalence of 8.1{\%} (95{\%} CI, 6.3 to 9.8). The prevalence of MGUS in relatives increased with age (1.9{\%}, 6.9{\%}, 11.6{\%}, 14.6{\%}, 21.0{\%} for ages 40-49, 50-59, 60-69, 70-79, ≥ 80 years, respectively; P < .001). Using similar MGUS detection methods, there was a higher risk of MGUS in relatives (age-adjusted risk ratio [RR], 2.6; 95{\%} CI, 1.9 to 3.4) compared with the reference population. The increased risk was seen among relatives of MM(RR, 2.0;95{\%}CI, 1.4 to 2.8) and MGUS probands (RR, 3.3; 95{\%} CI, 2.1 to 4.8). The increased risk of MGUS in first-degree relatives of MGUS or MM patients implies shared environment and/or genetics.",
author = "Vachon, {Celine M} and Kyle, {Robert A.} and Therneau, {Terry M} and Foreman, {Barbara J.} and Larson, {Dirk R.} and Colby, {Colin L.} and Phelps, {Tara K.} and Angela Dispenzieri and Kumar, {Shaji K} and Katzmann, {Jerry A.} and Rajkumar, {S Vincent}",
year = "2009",
doi = "10.1182/blood-2008-12-192575",
language = "English (US)",
volume = "114",
pages = "785--790",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "4",

}

TY - JOUR

T1 - Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance

AU - Vachon, Celine M

AU - Kyle, Robert A.

AU - Therneau, Terry M

AU - Foreman, Barbara J.

AU - Larson, Dirk R.

AU - Colby, Colin L.

AU - Phelps, Tara K.

AU - Dispenzieri, Angela

AU - Kumar, Shaji K

AU - Katzmann, Jerry A.

AU - Rajkumar, S Vincent

PY - 2009

Y1 - 2009

N2 - We examined whether monoclonal gammopathy of undetermined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS patients. Probands were recruited from a population-based prevalence study (MGUS) and the Mayo Clinic (MM). Serum samples were collected from first-degree relatives older than 40 years and subjected to electrophoresis and immunofixation. The prevalence of MGUS in relatives was compared with population-based rates. Nine-hundred eleven relatives of 232 MM and 97 MGUS probands were studied. By electrophoresis, MGUS was detected in 55 (6%) relatives, and immunofixation identified 28 additional relatives for an age- and sex-adjusted prevalence of 8.1% (95% CI, 6.3 to 9.8). The prevalence of MGUS in relatives increased with age (1.9%, 6.9%, 11.6%, 14.6%, 21.0% for ages 40-49, 50-59, 60-69, 70-79, ≥ 80 years, respectively; P < .001). Using similar MGUS detection methods, there was a higher risk of MGUS in relatives (age-adjusted risk ratio [RR], 2.6; 95% CI, 1.9 to 3.4) compared with the reference population. The increased risk was seen among relatives of MM(RR, 2.0;95%CI, 1.4 to 2.8) and MGUS probands (RR, 3.3; 95% CI, 2.1 to 4.8). The increased risk of MGUS in first-degree relatives of MGUS or MM patients implies shared environment and/or genetics.

AB - We examined whether monoclonal gammopathy of undetermined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS patients. Probands were recruited from a population-based prevalence study (MGUS) and the Mayo Clinic (MM). Serum samples were collected from first-degree relatives older than 40 years and subjected to electrophoresis and immunofixation. The prevalence of MGUS in relatives was compared with population-based rates. Nine-hundred eleven relatives of 232 MM and 97 MGUS probands were studied. By electrophoresis, MGUS was detected in 55 (6%) relatives, and immunofixation identified 28 additional relatives for an age- and sex-adjusted prevalence of 8.1% (95% CI, 6.3 to 9.8). The prevalence of MGUS in relatives increased with age (1.9%, 6.9%, 11.6%, 14.6%, 21.0% for ages 40-49, 50-59, 60-69, 70-79, ≥ 80 years, respectively; P < .001). Using similar MGUS detection methods, there was a higher risk of MGUS in relatives (age-adjusted risk ratio [RR], 2.6; 95% CI, 1.9 to 3.4) compared with the reference population. The increased risk was seen among relatives of MM(RR, 2.0;95%CI, 1.4 to 2.8) and MGUS probands (RR, 3.3; 95% CI, 2.1 to 4.8). The increased risk of MGUS in first-degree relatives of MGUS or MM patients implies shared environment and/or genetics.

UR - http://www.scopus.com/inward/record.url?scp=68249146525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68249146525&partnerID=8YFLogxK

U2 - 10.1182/blood-2008-12-192575

DO - 10.1182/blood-2008-12-192575

M3 - Article

VL - 114

SP - 785

EP - 790

JO - Blood

JF - Blood

SN - 0006-4971

IS - 4

ER -